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Heidelberg University

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PhD Student in HIV Pathogenesis, Human Lymphoid Models and Immunology Heidelberg University in Germany

Degree Level

PhD

Field of study

Immunology

Funding

The position is part-time at 65% under a temporary four-year TV-L contract, with collectively agreed remuneration at TV-L E13. Benefits include an attractive VBL company pension scheme, 30 days of vacation, and additional employee welfare and family-support benefits.

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Country

Germany

University

Heidelberg University

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Keywords

Immunology
Virology
Vaccinology
Biomedical Engineering
Biology
Tissue Engineering
Medical Science
Pathogen Biology
Microfluidic

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About this position

Heidelberg University Hospital’s Center for Integrative Infectious Disease Research (CIID) is seeking a PhD student to work within the Excellence Cluster SynthImmune and a DFG-funded research project on HIV pathogenesis and human lymphoid models.

The doctoral researcher will develop and optimize human lymphoid organ culture systems, including tonsil explants and aggregate cultures, to investigate adaptive immune responses and HIV-1 infection. Using tissue-engineering and microfluidic methods, the project will establish next-generation ex vivo lymphoid models with improved longevity, immune competence and suitability for long-term infection studies.

A major focus is understanding viral persistence and HIV latency in human tissue-based systems. The researcher will also study the HIV pathogenesis factor Nef and its effects on host immune functions, examine the anti-HIV activity of neutrophils, and investigate their contribution to antiviral immune responses. In addition, the models will support evaluation of de novo immune responses to vaccine candidates developed within SynthImmune.

The role involves analyzing and presenting scientific data, contributing to publications in international journals, and participating in collaborative research across virology, immunology, tissue engineering and microfluidics. The position is based at the Center for Integrative Infectious Disease Research, Heidelberg University Hospital, in Heidelberg, Germany.

Funding details

The position is part-time at 65% under a temporary four-year TV-L contract, with collectively agreed remuneration at TV-L E13. Benefits include an attractive VBL company pension scheme, 30 days of vacation, and additional employee welfare and family-support benefits.

What's required

Applicants must hold a Master's degree in Immunology, Biology, Biochemistry, Molecular Life Sciences, or a related field. A solid background in immunology and strong interest in infection biology and translational research are required. Experience with primary human immune cell culture and/or organoid or tissue-based model systems is advantageous, and practical expertise in flow cytometry is desirable. Excellent written and spoken English, scientific curiosity, enthusiasm for interdisciplinary research, and a collaborative, proactive and well-organized working style are expected. A valid measles immunity certificate is required for employment at the UKHD.

How to apply

Submit your application online through the Heidelberg University Hospital application portal. For further information, contact Kathrin Bajak at [email protected].

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