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University Hospital Würzburg

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PhD Student in Molecular Genetics and Cell Biology for Pediatric Acute Lymphoblastic Leukemia Research University Hospital Würzburg in Germany

Degree Level

PhD

Field of study

Cell Biology

Funding

Part-time employment at 65% TV-L, with salary according to TV-L E13 and an annual special payment. Benefits include an occupational retirement pension, subsidized canteen, company daycare, sports program, flexible working hours, JobBike, corporate benefits, and healthcare workshops.

Deadline

Dec 15, 2026

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Country

Germany

University

University Hospital Würzburg

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Keywords

Cell Biology
Molecular Biology
Biology
Medical Science
Oncogenomics
Omics
Long-read Sequencing
Bioinformatic
ML

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About this position

The Institute of Clinical Genetics and Genomic Medicine at University Hospital Würzburg is recruiting a PhD student to join an interdisciplinary cancer genomics research team focused on pediatric acute lymphoblastic leukemia (ALL), particularly B-other ALL cases that lack clearly risk-stratifying genetic alterations under conventional testing.

The José Carreras Leukämie-Stiftung-funded project will use long-read whole-genome sequencing, integrated multi-omic and clinical data analysis, and machine learning to characterize the genetic and epigenetic landscape of B-other ALL. The research aims to identify novel biomarkers that can improve risk stratification, support tailored treatment approaches, and contribute to better outcomes for children with leukemia.

The doctoral researcher will work closely with the ALL research group, bioinformatics team, biobank stakeholders, and members of European ALL study groups including AIEOP-BFM and ALLTogether. Laboratory work will include DNA, RNA, and protein isolation; sequencing library preparation; quality control; and sequencing using Illumina NovaSeq X plus, PacBio Revio, and Oxford Nanopore PromethION platforms. Additional molecular genetics work includes qPCR, Sanger sequencing, and MLPA.

The project also includes cell culture, CRISPR/Cas9 gene editing in ALL cell lines, cell viability assays, western blotting, flow cytometry, and computational analysis, interpretation, and visualization of genomic data. Promising candidate biomarkers will be investigated in functional in vitro models to assess their biological relevance.

The researcher will be embedded in an international, collaborative environment with access to advanced genomics facilities and GPU-based AI, high-performance computing, and data-analysis infrastructure. The role also involves publishing findings, presenting results at international scientific conferences, and supervising master’s and bachelor’s students.

Funding details

Part-time employment at 65% TV-L, with salary according to TV-L E13 and an annual special payment. Benefits include an occupational retirement pension, subsidized canteen, company daycare, sports program, flexible working hours, JobBike, corporate benefits, and healthcare workshops.

What's required

Applicants must hold a master’s degree in Biology, Molecular Biology, Biochemistry, Biomedical Sciences, or a related field; have hands-on experience with molecular biology techniques; demonstrate excellent written and spoken English; and be able to work independently and in an interdisciplinary team. A background in cancer genetics or cancer biology is advantageous, as is experience with bioinformatics tools and programming such as R or Python. Applicants with a university degree from a non-EU country must provide a long version of the certificate evaluation from the Central Office for Foreign Education.

How to apply

Apply through the University Hospital Würzburg career portal using the “Apply now” application link. Applicants with a non-EU university degree should provide the required long-form certificate evaluation.

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