PhD Student Position: RNP Granules in ALS Pathogenesis at Center for Regenerative Therapies Dresden Technische Universität Dresden in Germany

The Center for Regenerative Therapies Dresden (CRTD) at Technische Universität Dresden is offering a PhD student position focused on the study of ribonucleoprotein (RNP) granules in the pathogenesis of amyotrophic lateral sclerosis (ALS). This opportunity is part of the DFG-funded Research Training Group “Biomolecular Condensates: From Physics to Biological Functions” (RTG 3120), which provides a vibrant interdisciplinary research environment at the interface of physics and biology.

The project aims to characterize the role of RNP granules in motor neuron (MN) axons, investigating how these condensates protect mRNA and regulate local translation, and how their dysfunction contributes to ALS. The research leverages advanced technologies, including induced pluripotent stem cell (iPSC)-derived MNs, FUS-eGFP reporter lines for live-cell imaging, and custom microfluidic devices to study axonal granules and neuromuscular junctions. Key questions include the maintenance of diverse RNP granules, protein exchange dynamics, and mechanisms preventing granule fusion. The project will utilize dCas13d-mediated proximity labeling and pulse-chase experiments to identify protein-mRNA interactions and assess the impact of ALS mutations using isogenic iPSC models. The team will also explore therapeutic strategies using oligonucleotide 'bait RNAs' to reverse ALS pathogenesis.

The successful candidate will join a world-leading research community embedded in the CMCB, with access to state-of-the-art infrastructure and shared core facilities. The CRTD is closely linked to other major research centers in Dresden, fostering collaboration across cell biology, genomics, biophysics, tissue engineering, bioinformatics, and regenerative medicine. The position is remunerated according to salary group E 13 TV-L (65% of full-time weekly hours), funded by the DFG RTG 3120, and initially limited until March 31, 2030, with possible extension.

Applicants should hold a Master’s degree (or equivalent) in Biology or a related field, with experience in cell culture highly desired. Candidates must demonstrate the ability to work in an international, interdisciplinary team, possess excellent communication and social skills, and be fluent in English. Applications from women and candidates with disabilities are strongly encouraged. The application deadline is January 15, 2026.

To apply, submit a single PDF containing your CV, cover letter (describing research experience and interests), list of academic achievements/publications, degree certificates/transcripts, and contact information for at least two references via the TUD SecureMail Portal or by email to [email protected]. For more information about the research group, visit https://tud.link/vprn and https://dresdencondensates.org.