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Hellmich

10 months ago

PhD Studentship: Linking Myeloma Therapies, the Microbiome, and Immune Defence University of East Anglia in United Kingdom

Degree Level

PhD

Field of study

Cell Biology

Funding

Available

Deadline

Expired

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Country

United Kingdom

University

University of East Anglia

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Keywords

Cell Biology
Immunology
Biology
Innate Immunity
Medical Science
Microbiome Research
Gut Microbiota
Rna-seq
Mouse Model
Adaptive Immunity
Bioinformatic

About this position

[4-year fully-funded studentship including direct payment of tuition fees, annual stipend for living expenses (£20,780 for 2025/26), and a Research Training Support Grant each year.]

This fully-funded PhD studentship at the University of East Anglia offers an exciting opportunity to investigate the interplay between myeloma therapies, the gut microbiome, and immune defence mechanisms. Multiple myeloma affects thousands of individuals annually in the UK, and despite therapeutic advances, infection remains a significant cause of morbidity and mortality. Recent research highlights the impact of chemo- and immunotherapies on the gut microbiome, which in turn influences both innate and adaptive immune responses.

The project aims to elucidate how treatment-induced changes in the microbiome affect immune function and susceptibility to infection. The successful candidate will employ a combination of preclinical mouse models and analysis of stool samples from myeloma patients to assess microbiome alterations. In parallel, the research will explore the consequences of these changes on immune cell populations and infection responses.

Comprehensive training will be provided in in vivo techniques, including animal handling and the isolation of primary human samples under ethical approval. The student will also gain expertise in cellular biology methodologies such as DNA isolation, library preparation, sequencing, and bioinformatics for data analysis. The laboratory environment is highly supportive and collaborative, featuring weekly meetings, journal clubs, and encouragement to present research at conferences.

Supervision is provided by Dr. Hellmich, a clinical researcher with direct access to patient samples, and Prof. Rushworth, an experienced supervisor with a strong track record of guiding PhD students to successful postdoctoral careers. The project is based at Norwich Medical School, University of East Anglia.

Funding includes a 4-year studentship covering full tuition fees, an annual stipend (£20,780 for 2025/26), and a Research Training Support Grant. Applicants should hold at least a UK equivalent Bachelors (Honours) 2:1 degree and meet English language requirements (IELTS 6.5 overall, 6 in each category). The position is full-time, with a start date of 1 October 2026. For eligibility and application details, visit the university's application portal.

Funding details

Available

What's required

Applicants must hold at least a UK equivalent Bachelors (Honours) degree with a minimum of 2:1 classification. English language proficiency is required, with an IELTS score of 6.5 overall and at least 6 in each category. The position is full-time and starts on 1 October 2026. Experience in laboratory techniques, cellular biology, or bioinformatics is advantageous but not mandatory.

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Professors

Prof. at University of East Anglia

University Name
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United Kingdom

Research Interests

Immunology

Cell Biology

Biology

Innate Immunity

Health Science