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CNRS

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Post-doctoral Researcher: Molecular Characterization of the Connective Tissue Compartment in an Organ-on-Chip Platform CNRS in France

Degree Level

Postdoc

Field of study

Biochemistry

Funding

Funded by the ANR through the PLUME_2 project.

Deadline

Dec 1, 2026

Country flag

Country

France

University

CNRS

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Keywords

Biochemistry
Molecular Biology
Biomedical Engineering
Chemical Engineering
Materials Science
Medical Imaging
Biology
Medical Science
Extracellular Matrix Biology
Cell Culture Techniques
Microfluidic
Poroelasticity
Organ-on-chip Technology
Physics
Connective Tissue
Biomaterials

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About this position

The postdoctoral researcher will join the PLUME_2 consortium, a multidisciplinary project developing an organ-on-chip platform that integrates blood and lymphatic vessels to measure interstitial flows in real time and investigate tissue homeostasis. The work is centered on the connective tissue compartment of the device, with a focus on building and optimizing its matrix composition using exogenous materials and/or endogenous deposition by cells, on cellularized or devitalized tissues.

The position is hosted at Softmat (CNRS UMR 5623) in close collaboration with partners at LAAS-CNRS in Toulouse and LIMMS in Tokyo. The successful candidate will work within a collaborative environment combining microfluidics, poroelasticity, and biology, and will interact closely with a doctoral researcher already recruited at the Toulouse partner site as well as a biology technician supporting the project.

Research activities will involve human primary cell culture in 2D and 3D, formulation and characterization of biomaterials based on extracellular matrix components, and detailed biochemical and molecular analysis of the extracellular matrix produced by cells. The project also includes intracellular signaling studies, advanced imaging, quantitative image analysis, and collaboration with consortium partners to assess the structural and mechanical properties of the connective tissue model.

The project further aims to track the transport of model extracellular vesicles from the blood vessel compartment to the lymphatic vessel compartment through the connective tissue, linking tissue structure, transport, and homeostatic function in an engineered physiological model.

Funding details

Funded by the ANR through the PLUME_2 project.

How to apply

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