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Technical University of Denmark

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Postdoc in microbial production of self-assembling protein materials - BRIGHT Technical University of Denmark in Denmark

Degree Level

Postdoc

Field of study

Molecular Biology

Funding

Salary based on the collective agreement with the Danish Confederation of Professional Associations; supplements may be negotiated. The appointment is for 3 years, full-time.

Deadline

Jan 3, 2027

Country flag

Country

Denmark

University

Technical University of Denmark

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Keywords

Molecular Biology
Chemistry
Biomedical Engineering
Chemical Engineering
Materials Science
Biology
Protein Purification
Material Characterization
Protein Engineering
Biomanufacturing

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About this position

This postdoctoral position at the Technical University of Denmark is part of BRIGHT’s mission-oriented Novel Biomanufacturing-Enabled Materials programme (Mission 1A), which aims to develop PFAS-free biomaterials through biotechnology. The project focuses on microbial production platforms for natural self-assembling protein materials, with an emphasis on creating proteinaceous materials that can be produced efficiently, reproducibly and at relevant scale.

The work is highly experimental and spans the full chain from recombinant construct design and expression to protein purification, fermentation and material assembly studies. You will initially screen diverse natural self-assembling proteins in Escherichia coli and, where relevant, Bacillus subtilis, then take promising candidates forward into deeper studies of production, purification, higher-order structure formation and scale-up. The goal is to generate well-characterised lead materials for downstream testing and structural/functional characterisation.

The position sits within a broader BRIGHT research environment that connects AI-guided protein and peptide design, microbial engineering, cell-free prototyping, fermentation, materials processing, analytical quality control and structure-function characterisation. The programme brings together academic and industrial partners to build an integrated pipeline from molecular design to scalable biomanufacturing, with strong attention to manufacturability, cost, sustainability and industrial translation.

The immediate application focus is on batteries, selected as a proof-of-concept area because PFAS-containing materials are currently used in several battery components and because this sector demands high stability, processability and performance. More broadly, the platform is intended to support future PFAS-free materials for energy technologies, coatings, electronics and other high-value applications.

You will work across recombinant protein production, purification optimisation, microbial cultivation and fermentation, and the evaluation of protein self-assembly and material formation. The role also offers opportunities to draw on complementary expertise and research infrastructure across DTU for materials characterisation and downstream testing.

Funding details

Salary based on the collective agreement with the Danish Confederation of Professional Associations; supplements may be negotiated. The appointment is for 3 years, full-time.

What's required

A PhD in biotechnology, molecular biology, protein science or a related field is required. Candidates should have strong hands-on experience with molecular biology and genetic engineering, including design and construction of recombinant expression constructs, documented experience with recombinant protein production in Escherichia coli, strong experience with protein purification and optimisation of expression and purification workflows, experience with microbial cultivation and fermentation/bioreactor operation, and the ability to independently plan, execute and troubleshoot experimental work. Experience with protein expression or secretion in Bacillus subtilis or other Gram-positive hosts, self-assembling or fibrillar recombinant proteins, fermentation scale-up and process optimisation, characterisation of protein self-assembly and higher-order structures, or protein engineering is considered an advantage. As a formal qualification, the applicant must hold a PhD degree or equivalent.

How to apply

Submit the application online via the Apply now link. Upload all materials as one PDF in English, including a cover letter, CV, academic diplomas (MSc/PhD), and a list of publications. Applications must be submitted by 2027-01-03 23:59 Danish time.

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