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Dana-Farber Cancer Institute

Postdoctoral Fellow in Computational RNA Biology and Cancer Dana-Farber Cancer Institute in United States

Degree Level

Postdoc

Field of study

Cancer Biology

Funding

The advertised hiring range is $72,000–$76,385 per year. Individual salary is determined by factors including experience, skills, market conditions, internal equity, and organizational needs.

Deadline

Jan 5, 2027

Country flag

Country

United States

University

Dana-Farber Cancer Institute

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Keywords

Cancer Biology
Biology
Computational Biology
Functional Genomics
Medical Science
Melanoma
Bioinformatic
Transcriptomic
ML

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About this position

Dana-Farber Cancer Institute is recruiting a Postdoctoral Research Fellow in Computational RNA Biology and Cancer to join the Insco Laboratory in the Department of Medical Oncology in Boston, United States.

The Insco Lab studies how aberrant RNA processing and defects in nuclear RNA quality control contribute to cancer, with a particular focus on melanoma. A central theme is the dark transcriptome, including aberrant RNAs produced from repetitive genomic elements and mis-spliced transcripts. The group combines zebrafish models, mechanistic studies in human melanoma cell lines, and patient-derived datasets to identify RNA-driven oncogenic mechanisms and therapeutic vulnerabilities in high-risk melanoma.

The fellow will lead an independent project within a collaborative and supportive research environment. Research may include analysis of transcriptomic datasets generated using Oxford Nanopore direct RNA sequencing, PAR-CLIP, ribosome profiling, single-cell RNA sequencing, and DMS-MaP. Potential directions include dark transcriptome annotation, peptide prediction, RNA modification analysis, and RNA structure analysis.

The position is jointly mentored by David Liu, a melanoma medical oncologist and translational scientist with a software-engineering background. His laboratory develops biologically informed predictive models using statistical and machine-learning approaches. The fellow will contribute to computational tool development, reproducible workflows, data and bioinformatics infrastructure, research manuscripts, scientific presentations, and mentorship of trainees.

Dana-Farber Cancer Institute is a major cancer research and patient-care institution affiliated with Harvard Medical School hospitals. Its research community emphasizes rigorous, collaborative, inclusive, and patient-relevant cancer science.

Funding details

The advertised hiring range is $72,000–$76,385 per year. Individual salary is determined by factors including experience, skills, market conditions, internal equity, and organizational needs.

What's required

Applicants must hold a PhD or equivalent doctoral degree in biomedical, computational, or related sciences. Required qualifications include experience analyzing complex transcriptomic or functional genomics datasets, proficiency in Python and R, and experience using high-performance computing environments for large-scale biological datasets. Experience in RNA biology, transcriptional biology, and/or cancer biology is desirable; experience in computational modeling of protein complexes is a plus. Candidates should demonstrate strong critical-thinking, scientific writing, and communication skills, a record of scientific accomplishment including at least one peer-reviewed original research publication, and the ability to work independently and collaboratively.

How to apply

Apply through the external Nature Careers application page linked in the advert. Submit the requested application materials and supporting documents through the application portal.

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