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Masaryk University

Just Landed

Postdoctoral Fellow in Lipid Nanoparticles for mRNA Drug Delivery and Cancer Immunotherapy Masaryk University in Czech Republic

Degree Level

Postdoc

Field of study

Chemistry

Funding

The position offers a full-time contract, an attractive salary supported by prestigious funding including ERC grants, six weeks of paid holiday, medical insurance, contributions toward meals and kindergarten or pension schemes, a Multisport card, mental health care, sports lessons on campus, and other benefits. Flexible working hours and support for further education and professional development are provided.

Deadline

Oct 31, 2027

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Country

Czech Republic

University

Masaryk University

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Keywords

Chemistry
Biomedical Engineering
Materials Science
Drug Delivery
Biophysics
Biology
Structural Biology
Computational Chemistry
Molecular Dynamics
Medical Science
Statistical Mechanics
Soft Matter Physics
Lipid Nanoparticles
Physics

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About this position

Masaryk University’s Central European Institute of Technology (CEITEC MU) is seeking a Postdoctoral Fellow to join the Robert Vácha Research Group in Brno, Czech Republic.

The project focuses on lipid nanoparticles and related delivery systems for mRNA-based cancer immunotherapy vaccines. These systems must deliver therapeutic mRNA reliably to the cytosol while maintaining safety, long-term stability, high loading efficiency, uniform particle size, and suitability for scalable manufacturing.

The postdoctoral researcher will use coarse-grained molecular simulations, complemented by in-house experimental validation, to investigate how lipid- and polymer-based nanoparticles assemble and disassemble under physiologically relevant conditions. These include extracellular fluids, endosomal compartments, and the cytosol. The resulting molecular insights will support the rational design of improved next-generation mRNA delivery carriers.

The researcher will work in a structural biology environment with access to CEITEC MU core facilities, state-of-the-art equipment, experienced technical staff, and opportunities for collaboration, training, and professional development.

Funding details

The position offers a full-time contract, an attractive salary supported by prestigious funding including ERC grants, six weeks of paid holiday, medical insurance, contributions toward meals and kindergarten or pension schemes, a Multisport card, mental health care, sports lessons on campus, and other benefits. Flexible working hours and support for further education and professional development are provided.

What's required

Applicants must hold a PhD in biophysics, soft matter physics, physical chemistry, computational chemistry, statistical mechanics, or a related field. Experience with molecular dynamics simulations using packages such as GROMACS, OPENMM, LAMMPS, NAMD, or AMBER at atomistic or coarse-grained level is advantageous. Good spoken and written English is required. Good communication and interpersonal skills, motivation, and a collaborative mindset are desirable.

How to apply

Submit a CV, motivation letter, list of publications, and contact details for at least two references through the e-application. For e-application difficulties, contact Petra Linhartová at [email protected].

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