Postdoctoral Position: Lymph vessel-on-a-chip – Muscle Cell Contractility and Lymphedema KU Leuven in Belgium

This postdoctoral position at KU Leuven offers an exciting opportunity to advance research in lymphatic vessel biology and lymphedema. The successful candidate will join the MAtrix / Mechanobiology & Tissue Engineering research group, led by Prof. Hans Van Oosterwyck, which is renowned for its pioneering work in cellular force inference and microvascular formation. The project centers on developing a novel lymph vessel-on-a-chip platform, integrating lymphatic endothelial cells (LECs) and lymphatic muscle cells (LMCs) in a co-culture system with controlled fluid perfusion. This innovative model will be used to investigate the mechanisms of LEC–LMC communication and their impact on muscle cell contractility, providing new insights into lymphedema pathophysiology.

The research is conducted in close collaboration with Prof. An Zwijsen’s laboratory at the Centre for Molecular and Vascular Biology, KU Leuven, which specializes in BMP signaling in vascular development and disease. The project leverages both in vitro and in vivo models, including a mouse model of lymphedema, to explore the role of BMP signaling components. Candidates will address bioengineering challenges related to biofabrication, image data acquisition and processing, and develop a deep mechanistic understanding of cellular signaling in the lymphatic system.

Applicants should have a PhD in biomedical engineering, biotechnology, or a related field, with proven expertise in microfluidics, 3D cell culture, hydrogel engineering, and biofabrication. Experience with 3D bioprinting, confocal fluorescence microscopy, live cell imaging, and image processing (including programming for image analysis workflows) is highly desirable. A strong foundation in continuum mechanics of materials and numerical simulation is expected. The ideal candidate will demonstrate excellent scientific writing, strong communication skills, and a collaborative approach, supported by a publication record in biofabrication and vascular biology.

The MAtrix / Mechanobiology & Tissue Engineering group is based at the Leuven Chem&Tech / Leuven Nanocentre, which provides access to state-of-the-art facilities for optical microscopy, nanoscopy, micro/nano/biofabrication, and biosensing. The research environment is multidisciplinary, international, and highly collaborative, with close partnerships with medical and molecular biology experts. The initial appointment is for one year, with the possibility of extension up to three years, offering a dynamic and supportive setting for career development.

KU Leuven is one of Europe’s oldest and most prestigious universities, consistently ranked among the world’s top 100. The university is located in Leuven, a vibrant town in Belgium known for its exceptional quality of life and welcoming academic community. KU Leuven is committed to diversity, inclusion, and equal opportunity, fostering a respectful and socially safe environment for all researchers.

Interested candidates should apply online via the KU Leuven job portal. For further information, contact Prof. Hans Van Oosterwyck at [email protected]. Applications must be submitted by April 30, 2026.