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University of Wisconsin-Madison

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Postdoctoral Research Associate in Modeling Vascular Anomalies Using Human iPSCs and Zebrafish University of Wisconsin in United States

Degree Level

Postdoc

Field of study

Molecular Biology

Funding

The salary follows the NRSA/NIH Postdoctoral trainee payscale. No additional details about stipend amount or tuition coverage are provided.

Deadline

Jan 14, 2027

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Country

United States

University

University of Wisconsin-Madison

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Keywords

Molecular Biology
Biology
Vascular Biology
Developmental Biology
Genetic

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About this position

The Lawson Lab will relocate to the Department of Dermatology at the University of Wisconsin in Madison in January 2027 and is recruiting multiple postdoctoral research associates for projects focused on vascular anomalies. Projects can be tailored to candidates’ interests in consultation with the principal investigator, Nathan D. Lawson.

One research direction models vascular anomalies in human induced pluripotent stem cells (iPSCs). The postdoctoral researcher will generate and characterize human iPSC lines carrying conditional mutations associated with vascular anomalies, including activating mutations in GNAQ, MEK, PIK3CA and RAS, as well as loss-of-function mutations in RASA1 and EPHB4. The work will involve designing and implementing genetic targeting strategies, establishing conditionally activated or deleted iPSC lines, and assessing endothelial-cell differentiation and morphogenesis.

The iPSC studies will use resources from the UW Human Stem Cell Core and WiCell. Collaborative projects with groups in UW Dermatology will apply organ-on-a-chip models to investigate tissue-level phenotypes. Comparative omics approaches will be used to identify pathways commonly affected by candidate variants, while ongoing work on the cellular origins of vascular anomaly lesions will inform future studies of non-endothelial cell types.

A second research direction uses zebrafish models of capillary malformation–arteriovenous malformation syndrome and Sturge-Weber syndrome. The researcher will analyze mutant zebrafish embryos and adults using serial confocal imaging, immunostaining and single-cell RNA sequencing. Projects include studying mosaic lesions, identifying second-hit mutations through exome and whole-genome sequencing, testing candidate genes with CRISPR, and developing conditional alleles to investigate cell autonomy and post-embryonic disease progression.

The research environment combines developmental biology, genetics, molecular biology, stem-cell modeling, zebrafish genetics, genomics and collaborative dermatology research.

Funding details

The salary follows the NRSA/NIH Postdoctoral trainee payscale. No additional details about stipend amount or tuition coverage are provided.

What's required

Applicants require a PhD in the Biological Sciences, ideally with a concentration in developmental biology and/or genetics. Expertise with genetic approaches in animal or human iPSC models is required, and a broad background in molecular biology is preferred. Candidates must be highly motivated and technically accomplished, as documented by an exceptional publication record. Applicants should submit a brief cover letter of one page or less and a CV; only applicants selected for initial consideration will subsequently be asked for letters of reference.

How to apply

Email a brief cover letter of one page or less and a CV to Nathan D. Lawson at [email protected]. Applicants selected for initial consideration will later be contacted for letters of reference.

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