University of Wisconsin-Madison
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Postdoctoral Research Associate in Modeling Vascular Anomalies Using Human iPSCs and Zebrafish University of Wisconsin in United States
Degree Level
Postdoc
Field of study
Molecular Biology
Funding
The salary follows the NRSA/NIH Postdoctoral trainee payscale. No additional details about stipend amount or tuition coverage are provided.
Deadline
Jan 14, 2027
Country
United States
University
University of Wisconsin-Madison
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About this position
The Lawson Lab will relocate to the Department of Dermatology at the University of Wisconsin in Madison in January 2027 and is recruiting multiple postdoctoral research associates for projects focused on vascular anomalies. Projects can be tailored to candidates’ interests in consultation with the principal investigator, Nathan D. Lawson.
One research direction models vascular anomalies in human induced pluripotent stem cells (iPSCs). The postdoctoral researcher will generate and characterize human iPSC lines carrying conditional mutations associated with vascular anomalies, including activating mutations in GNAQ, MEK, PIK3CA and RAS, as well as loss-of-function mutations in RASA1 and EPHB4. The work will involve designing and implementing genetic targeting strategies, establishing conditionally activated or deleted iPSC lines, and assessing endothelial-cell differentiation and morphogenesis.
The iPSC studies will use resources from the UW Human Stem Cell Core and WiCell. Collaborative projects with groups in UW Dermatology will apply organ-on-a-chip models to investigate tissue-level phenotypes. Comparative omics approaches will be used to identify pathways commonly affected by candidate variants, while ongoing work on the cellular origins of vascular anomaly lesions will inform future studies of non-endothelial cell types.
A second research direction uses zebrafish models of capillary malformation–arteriovenous malformation syndrome and Sturge-Weber syndrome. The researcher will analyze mutant zebrafish embryos and adults using serial confocal imaging, immunostaining and single-cell RNA sequencing. Projects include studying mosaic lesions, identifying second-hit mutations through exome and whole-genome sequencing, testing candidate genes with CRISPR, and developing conditional alleles to investigate cell autonomy and post-embryonic disease progression.
The research environment combines developmental biology, genetics, molecular biology, stem-cell modeling, zebrafish genetics, genomics and collaborative dermatology research.
Funding details
The salary follows the NRSA/NIH Postdoctoral trainee payscale. No additional details about stipend amount or tuition coverage are provided.
What's required
Applicants require a PhD in the Biological Sciences, ideally with a concentration in developmental biology and/or genetics. Expertise with genetic approaches in animal or human iPSC models is required, and a broad background in molecular biology is preferred. Candidates must be highly motivated and technically accomplished, as documented by an exceptional publication record. Applicants should submit a brief cover letter of one page or less and a CV; only applicants selected for initial consideration will subsequently be asked for letters of reference.
How to apply
Email a brief cover letter of one page or less and a CV to Nathan D. Lawson at [email protected]. Applicants selected for initial consideration will later be contacted for letters of reference.
Make your next move.
Prepare your application
Review drafts and confirm requirements with the university.
Make your next move.
Prepare your application
Review drafts and confirm requirements with the university.