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Queen Mary University of London
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Postdoctoral Research Associate in Spatial Transcriptomics of ADPKD and JAK Inhibition Queen Mary University of London in United Kingdom
Degree Level
Postdoc
Field of study
Inflammation
Funding
This is a full-time, fixed-term 12-month postdoctoral position with a salary of £39,187–£42,993 per annum. The post is funded by Barts Charity. Benefits include a pension scheme, 30 days’ leave per annum pro rata, a season ticket loan scheme, professional development opportunities and flexible working and family-friendly policies.
Deadline
Dec 7, 2026
Country
United Kingdom
University
Queen Mary University of London
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About this position
Queen Mary University of London is seeking a postdoctoral researcher to lead the bioinformatics component of a translational project on Autosomal Dominant Polycystic Kidney Disease (ADPKD). The project, funded by Barts Charity, is hosted in Dr Maria Fragiadaki’s laboratory at the William Harvey Research Institute, within the Centre for Translational Medicine and Therapeutics at the John Vane Science Centre in London.
The research will use 10x Genomics Visium spatial transcriptomics to investigate how JAK inhibition influences ADPKD progression and inflammation. The postdoctoral researcher will analyse existing spatial transcriptomics datasets, perform digital microdissection by identifying cyst-associated regions, and uncover localised inflammatory niches within diseased kidney tissue.
A major focus will be the analysis of ligand–receptor interactions and cellular crosstalk among epithelial cells, immune cells and fibroblasts following JAK inhibition. The researcher will develop and drive computational workflows for data acquisition, integration, deconvolution and cell–cell communication analysis, helping to reveal the spatial organisation and molecular mechanisms underlying treatment response.
The role provides an opportunity to contribute to high-impact translational research in a multidisciplinary environment combining bioinformatics, spatial biology, inflammation research and renal disease investigation.
Funding details
This is a full-time, fixed-term 12-month postdoctoral position with a salary of £39,187–£42,993 per annum. The post is funded by Barts Charity. Benefits include a pension scheme, 30 days’ leave per annum pro rata, a season ticket loan scheme, professional development opportunities and flexible working and family-friendly policies.
What's required
Applicants must hold a PhD, or be close to completion, in Bioinformatics, Computational Biology, or a quantitative biological field. Documented experience managing spatial or single-cell RNA transcriptomics workflows and strong programming proficiency in R or Python are essential. Experience in data acquisition, integration, deconvolution and calculating cell-cell communication networks is highly desirable. Candidates must be able to work independently, drive computational pipelines and communicate discoveries effectively within a multidisciplinary translational research team.
How to apply
Apply through the Queen Mary University of London jobs portal using the advertised opportunity. Review the job pack and submit the required application materials before 7 December 2026 at 23:55.
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