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University of Leeds

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Postdoctoral Research Fellow in Mass Spectrometry Structural Biology and TDP-43 Oligomerisation University of Leeds in United Kingdom

Degree Level

Postdoc

Field of study

Chemistry

Funding

Postdoctoral Research Fellow employment at the University of Leeds; the post is a fixed-term research position. The post advertises standard university staff benefits, but no stipend or tuition funding is mentioned.

Deadline

Oct 7, 2026

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Country

United Kingdom

University

University of Leeds

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Keywords

Chemistry
Biomedical Engineering
Biology
Structural Biology
Protein Chemistry
Mass Spectrometry
Neuropsychology
Medical Science
Neurodegenerative Disease
Amyotrophic Lateral Sclerosis

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About this position

Postdoctoral Research Fellow in Mass Spectrometry Structural Biology at the University of Leeds

This post is a research fellow opening at the University of Leeds in the United Kingdom, based in Leeds, England. The project focuses on mass spectrometry, structural biology, structural proteomics, and protein biochemistry, with a strong disease focus on Amyotrophic Lateral Sclerosis (ALS) and the RNA-binding protein TDP-43.

The successful candidate will work on a collaborative project investigating the molecular mechanisms of TDP-43 self-assembly and mis-oligomerisation in ALS. The research combines advanced mass spectrometry, cellular models, protein biochemistry, and structural biology approaches to understand how TDP-43 oligomerisation changes in disease and to identify potential therapeutic strategies.

The role is based in the laboratory of Dr Antonio Calabrese, Associate Professor, and involves close collaboration with researchers at the Astbury Centre and partners in Sheffield, Essex, and the Netherlands. The post specifically highlights expertise in chemical crosslinking mass spectrometry (XL-MS), including photoactivatable crosslinkers, and work primarily in vitro.

Applicants should have a PhD or be close to completion in Chemistry, Biochemistry, Biophysics, or a related discipline. Strong experience in structural mass spectrometry and an interest in analytical techniques are emphasized.

Deadline: 2026-10-07.

How to apply: Visit the University of Leeds vacancy page and apply through the official jobs portal. For informal enquiries, contact Dr Antonio Calabrese at [email protected].

Funding details

Postdoctoral Research Fellow employment at the University of Leeds; the post is a fixed-term research position. The post advertises standard university staff benefits, but no stipend or tuition funding is mentioned.

What's required

Applicants should have a PhD or be close to completion in Chemistry, Biochemistry, Biophysics or a related discipline. Extensive hands-on expertise in mass spectrometry, especially structural proteomics, is required, along with an interest in analytical techniques. Significant experience in structural mass spectrometry and chemical crosslinking mass spectrometry (XL-MS) is expected.

How to apply

Use the University of Leeds vacancy page to view the full advert and submit an application through the official jobs portal. For queries about the post, contact Dr Antonio Calabrese by email.

More information can be found here

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