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University of Cambridge

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PhD in Probing the Mechanism of Programmed Axon Death Using Protein Design University of Cambridge in United Kingdom

Degree Level

PhD

Field of study

Neurology

Funding

Competition-funded PhD project. Funding is available for the October 2027/28 academic year, with Cambridge Trust and Gates Cambridge (round 2) deadlines noted for funding eligibility. Gates US applications (round 1) close 2026-10-14; Cambridge Trust/Gates Cambridge (round 2) deadline is 2026-12-08. Funding is not available for Lent or Easter 2027 places, so other funding would be needed for those starts.

Deadline

Dec 8, 2026

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Country

United Kingdom

University

University of Cambridge

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Keywords

Neurology
Biology
Neuropsychology
Medical Science
Neurodegenerative Disease

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About this position

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death, SARM1, NMNAT2, and protein design.

The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modification.

Research interests include neuroscience, neurology, axon biology, neurodegeneration, protein engineering, and structural biology. The successful candidate will gain experience in molecular cloning, site-directed mutagenesis, enzyme assays, primary and hiPSC-derived neuron cultures, transfection, and structural analysis.

This is a competition-funded PhD project for students worldwide at the University of Cambridge in Cambridge, United Kingdom. Funding notes mention Cambridge Trust and Gates Cambridge deadlines for eligibility, and that funding is not available for Lent or Easter 2027 starts.

To apply, use the Cambridge postgraduate application portal and submit before the relevant funding deadline if you want to be considered for funding. The post also mentions a Research MPhil link, but the advertised opportunity is the PhD project.

Funding details

Competition-funded PhD project. Funding is available for the October 2027/28 academic year, with Cambridge Trust and Gates Cambridge (round 2) deadlines noted for funding eligibility. Gates US applications (round 1) close 2026-10-14; Cambridge Trust/Gates Cambridge (round 2) deadline is 2026-12-08. Funding is not available for Lent or Easter 2027 places, so other funding would be needed for those starts.

What's required

Applicants should be interested in neuroscience and protein design, and be willing to develop skills in molecular cloning, site-directed mutagenesis, enzyme assays, primary and hiPSC-derived neuron cell cultures, transfection, and structural analysis. The project is open to students worldwide. No specific degree class, GPA, or language-test requirement is stated in the post.

How to apply

Apply through the University of Cambridge online portal using the PhD application link. If you want funding consideration, submit before the relevant funding deadlines and indicate all funding sources you are eligible for.

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