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Eawag, Swiss Federal Institute of Aquatic Science and Technology

Postdoctoral Researcher in Environmental Analysis and Fate of Synthetic Oligonucleotide Therapeutics in Aquatic Environments Eawag – Swiss Federal Institute of Aquatic Science and Technology in Switzerland

Degree Level

Postdoc

Field of study

Chemistry

Funding

Available

Deadline

Dec 31, 2026

Country flag

Country

Switzerland

University

Eawag, Swiss Federal Institute of Aquatic Science and Technology

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Keywords

Chemistry
Environmental Science
Biology
Mass Spectrometry
Wastewater Treatment
Ecotoxicology

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About this position

Eawag – the Swiss Federal Institute of Aquatic Science and Technology – is recruiting a postdoctoral researcher for a two-year interdisciplinary study on the environmental analysis and fate of synthetic oligonucleotide therapeutics in aquatic environments.

Synthetic oligonucleotides are an expanding class of nucleic-acid-based therapeutics. Chemical modifications that protect these compounds from enzymatic degradation in the human body may also influence their persistence, transformation, and biological activity after excretion through wastewater treatment plants and release into aquatic environments. The project will establish the analytical foundation needed to investigate their environmental occurrence and persistence and support future environmental risk assessment.

Based in the Department of Environmental Chemistry (Uchem), the successful researcher will work with an interdisciplinary consortium of environmental chemists and molecular biologists from Eawag and ETH Zürich. The research will combine environmental chemistry, analytical chemistry, molecular biology, and aquatic environmental research.

  • Develop mass-spectrometry-based analytical procedures for modified oligonucleotides (mONs).
  • Apply the methods to environmental samples from potential emission hotspots in Switzerland.
  • Evaluate mON transformation in laboratory wastewater and water-model systems.

The role offers an opportunity to contribute to fundamental research at the interface of emerging therapeutics, wastewater, environmental fate, and aquatic ecosystem protection, while collaborating with researchers and engaging with regulators and other stakeholders.

Funding details

Available

What's required

Applicants must hold a PhD in environmental chemistry, analytical chemistry, biochemistry, molecular biology, or a related discipline. Experience with liquid chromatography/tandem mass spectrometry, high-resolution mass spectrometry, sample preparation procedures, and related data-evaluation pipelines is required. Prior experience with HRMS of biomolecules is advantageous. Proficiency in English is required. Candidates should demonstrate motivation for fundamental research in an environmental context, teamwork, communication, and collaborative skills, interest in advising students, and willingness to engage with regulators and stakeholders. The application must include a cover letter, a concise statement of previous education and research experience, a 1–2 page statement of research interests, CV, publication list, copies of academic qualifications, and contact details for three academic references.

How to apply

Apply through the online application webpage by submitting a cover letter, research-interest statement, CV, publication list, academic qualification copies, and contact information for three academic references. Applications sent by other means will not be considered.

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