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ETH Zurich

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Postdoctoral Researcher in Neuroblastoma Tumor Microenvironment Metabolism ETH Zurich in Switzerland

Degree Level

Postdoc

Field of study

Biology

Funding

A competitive salary is offered in line with ETH Zurich regulations.

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Country

Switzerland

University

ETH Zurich

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Keywords

Biology
Vascular Biology
Single-cell Analysis
Medical Science
Tumor Microenvironment
Pediatric Oncology
Tumor Immunology
Cancer Metabolism
Immunometabolism
Neuroblastoma
Metabolomic
Spatial Transcriptomic

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About this position

This postdoctoral project investigates how the metabolic tumor microenvironment of pediatric neuroblastoma is organized, reprogrammed and potentially exploited for treatment. The position is part of the NCCR Children and Cancer consortium and connects the Laboratory of Exercise and Health at ETH Zurich, headed by Prof. Katrien De Bock, with the Morscher Lab at University Children's Hospital Zurich, led by Dr. Raphael Morscher.

The researcher will establish and characterize genetic and/or orthotopic mouse models of neuroblastoma and use them to study how tumors reshape their metabolic niche. Particular emphasis will be placed on the interaction between tumor blood vessels, immune cells and metabolism, including vascular diversity, organization, hypoxia, and nutrient and oxygen delivery.

The work will profile the immune tumor microenvironment and its relationship with tumor vasculature using approaches such as single-cell and spatial transcriptomics, metabolomics, imaging and functional vascular/metabolic assays. The project will also test interventions at the immune–vascular interface, including vascular normalization and HEV-like reprogramming, to identify actionable metabolic vulnerabilities.

Embedded in the wider NCCR network, the postdoctoral researcher will integrate metabolic, vascular and immune data with collaborators working on human patient samples, genetic mouse models and systems-level analyses of pediatric cancer. The role provides access to state-of-the-art infrastructure at ETH Zurich and University Children's Hospital Zurich, with joint mentorship from two complementary laboratories.

Funding details

A competitive salary is offered in line with ETH Zurich regulations.

What's required

Applicants must hold a PhD in cancer biology, vascular biology, immunometabolism, or a related field; have a strong research background in cancer metabolism, vascular biology, or immune metabolism; and possess hands-on experience with mouse models of cancer. Familiarity with imaging, flow cytometry, transcriptomics, or related cellular and molecular tumor-biology techniques is an asset. Strong communication skills, enthusiasm for collaboration across two laboratories and a consortium, and advanced proficiency in English are required.

How to apply

Submit an online application through the application portal with a CV, a brief one-page statement of motivation and research interests, and contact details for two references. Applications by email or postal service will not be considered.

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