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ETH Zurich

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Postdoctoral Researcher in Neurovascular Models and B-Cell Pathobiology in Multiple Sclerosis ETH Zurich in Switzerland

Degree Level

Postdoc

Field of study

Biomedical Engineering

Funding

The position is fully funded for 2.5 years, with annual contract renewal. ETH Zurich benefits include public transport season tickets, car sharing, sports facilities, childcare, and pension benefits.

Deadline

Dec 15, 2026

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Country

Switzerland

University

ETH Zurich

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Keywords

Biomedical Engineering
Biology
Neuropsychology
Neuroinflammation
Medical Science
Drug Development
Multiple Sclerosis
Blood-brain Barrier
Psychoneuroimmunology
bio engineering

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About this position

ETH Zurich and Novartis Biomedical Research are seeking a Postdoctoral Researcher for a collaborative project in Basel, Switzerland. The work sits at the interface of academic and industrial research and focuses on neuroimmunology, bioengineering, and therapeutic development.

The project will develop and apply advanced human in vitro models of the blood-brain barrier to investigate mechanisms driving disease progression in Multiple Sclerosis. Building on an established multicellular, flow-enabled human blood-brain barrier platform, the researcher will incorporate neuroimmune components including microglia and human B cells to establish a disease-relevant model of progressive MS.

The resulting neurovascular model will be used to study B-cell trafficking, compartmentalization within the central nervous system, persistence, and therapeutic depletion. The research will also support evaluation of next-generation brain-penetrant B-cell-depleting therapies, generating insights into neuroinflammatory disease mechanisms and potential innovative treatments.

The researcher will work with the Bio Engineering Laboratory in ETH Zurich’s Department of Biosystems Science and Engineering in Basel, in close collaboration with Novartis Biomedical Research. The environment is international, interdisciplinary, and highly interactive, with access to expertise and resources from both academic and industrial partners.

Funding details

The position is fully funded for 2.5 years, with annual contract renewal. ETH Zurich benefits include public transport season tickets, car sharing, sports facilities, childcare, and pension benefits.

What's required

Applicants should have a background in immunology, neuroimmunology, neuroscience, bioengineering, biotechnology, or a related discipline. Experience with advanced in vitro models, blood-brain barrier biology, complex cell culture systems, neuroinflammation, or immune cell biology is highly desirable. Experience with human immune cells, flow cytometry, fluorescence microscopy, molecular biology techniques, or transcriptomics is advantageous. Good communication skills, a proactive work attitude, academic excellence, professionalism, self-driven initiative, fluent written and oral English, and willingness to work in an interactive interdisciplinary international environment are required. Applications should include a half-page motivation statement, complete academic transcripts, an up-to-date CV, and at least two reference letters or referee contact details.

How to apply

Submit the required documents through the online application portal by December 15, 2026. Applications by email or post will not be considered; contact Professor Andreas Hierlemann only for position information, not applications.

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