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University of Cambridge

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PhD in Retrograde Mitochondrial Signalling, Epigenetic Reprogramming, and Neuroinflammation in Progressive Multiple Sclerosis University of Cambridge in United Kingdom

Degree Level

PhD

Field of study

Biology

Funding

Competition-funded PhD project for students worldwide. Funding is available for October 2027/28 entry, with Cambridge Trust and Gates Cambridge round 2 deadline on 8 December 2026; Gates US round 1 closes 14 October 2026. Funding is not available for Lent or Easter 2027 places, and applicants after funding deadlines will need other funding in place.

Deadline

Dec 8, 2026

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Country

United Kingdom

University

University of Cambridge

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Keywords

Biology
Neuropsychology
Neuroinflammation
Medical Science
Multiple Sclerosis

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About this position

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on retrograde mitochondrial signalling, epigenetic reprogramming, glial toxicity, and neuroinflammation in progressive multiple sclerosis.

The project focuses on how mitochondrial dysfunction and mitochondrial stress trigger nuclear signalling and epigenetic changes that may drive astrocytes toward a dysfunctional disease-associated radial glia-like (DARG) phenotype. The work is strongly research-oriented and combines neuroscience, medical science, biology, and advanced molecular approaches.

Students will work with patient-derived iNSCs, control lines, post-mortem brain samples, and public human datasets such as snRNA-seq and spatial transcriptomics. Methods mentioned include RNA-seq, ATAC-seq, ChIP-seq, MeDIP-seq, CRISPR-Cas9 gene editing, molecular biology, cell culture, and potentially in vivo validation using brain organoids and, later, in utero xenotransplantation if justified by progress.

The project is supervised by Dr S Pluchino at the University of Cambridge. It is a competition-funded PhD project for students worldwide. Funding information notes Cambridge Trust and Gates Cambridge deadlines, with eligibility depending on applying before the relevant funding cut-offs.

Key interests include progressive multiple sclerosis, mitochondrial signalling, epigenetics, glial biology, neuroinflammation, senescence, and stem cell-based disease modelling. Applicants should be prepared for a mechanistic, multi-omics, and translational neuroscience project.

Deadline: Cambridge Trust / Gates Cambridge round 2 deadline: 8 December 2026. Gates US round 1 deadline: 14 October 2026.

Funding details

Competition-funded PhD project for students worldwide. Funding is available for October 2027/28 entry, with Cambridge Trust and Gates Cambridge round 2 deadline on 8 December 2026; Gates US round 1 closes 14 October 2026. Funding is not available for Lent or Easter 2027 places, and applicants after funding deadlines will need other funding in place.

What's required

Applicants should be interested in progressive multiple sclerosis, mitochondrial biology, epigenetics, glial cell biology, and neuroinflammation. The project mentions experience or willingness to learn omics technologies, gene editing, molecular biology, cell culture, and potentially in vivo techniques. Work will use patient-derived iNSCs, post-mortem brain samples, and public human datasets; prior experience with RNA-seq, ATAC-seq, ChIP-seq, MeDIP-seq, or CRISPR-Cas9 would be relevant but is not explicitly required.

How to apply

Register your interest through the FindAPhD project page and submit your application to the University of Cambridge. Make sure to indicate all funding competitions you are eligible for. Check the Gates and Cambridge Trust funding deadlines before applying.

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