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INSERM
Just Landed
1 days ago
Postdoctoral Researcher in Protein Biochemistry and Cell Signaling Inserm in France
Degree Level
Postdoc
Field of study
Cell Biology
Funding
Available
Deadline
Mar 31, 2027
Country
France
University
INSERM
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About this position
This postdoctoral project is part of PIMPERK, an interdisciplinary research effort funded by ANR that investigates how PIM kinases regulate the eIF2α kinase PERK and how this phosphorylation-dependent control affects protein secretion, cellular stress responses, and cell differentiation.
The successful candidate will join Inserm research units UMR_S 1236 and UMR_S 1242 in Rennes, Brittany, within a collaborative environment that combines expertise in plasma cell biology, B cell immunology, endoplasmic reticulum biology, ERN1 signaling, and cancer biology. The work is embedded in the local research infrastructure and benefits from access to advanced light and electron microscopy, flow cytometry, proteomics-related technologies, and animal facilities.
The project is centered on understanding the molecular mechanisms that regulate PERK activity and its interaction with PIM kinases. The postdoctoral researcher will design and carry out experiments on protein-protein interactions, kinase-dependent signaling, and protein phosphorylation, then use cellular models to assess the effects of PERK regulation on signaling pathways, cell physiology, and differentiation.
The role also includes applying and developing protein biochemistry and cell biology approaches to dissect these mechanisms, analyzing and documenting data for robust scientific output, and contributing to publications, reports, and conference presentations. The position is embedded in a team-oriented environment with close interaction between the two research groups and opportunities to co-supervise Master's students.
Overall, this is a highly interdisciplinary postdoctoral project linking protein biochemistry, kinase signaling, endoplasmic reticulum function, and cellular differentiation in a research setting focused on fundamental mechanisms and translational relevance to cancer biology.
Funding details
Available
What's required
PhD or equivalent in biochemistry, cell biology, molecular biology or a closely related discipline. Candidates with 3–4 years of postdoctoral experience are particularly encouraged to apply. Required expertise includes strong protein biochemistry and cellular signaling skills, ideally in stress-response pathways or kinase-dependent regulation; hands-on protein-protein interaction analysis; solid knowledge of protein phosphorylation, kinase signaling and protein function characterization; practical experience in mammalian cell culture and cell-based functional assays; and demonstrated ability to independently design and lead research projects, interpret complex data, and publish findings. Desirable experience includes phosphoproteomics, proteomics or mass spectrometry-based approaches, endoplasmic reticulum biology, cellular stress responses or protein secretion, and immunoprecipitation/co-immunoprecipitation. Applicants should have scientific curiosity, creativity, strong organizational skills, scientific rigor, initiative, strong interpersonal and communication skills, and professional proficiency in written and spoken English; French is an advantage but not required.
How to apply
Submit a single PDF application by email to both scientific supervisors. Include a detailed CV with publications and relevant technical expertise, a motivation letter, and contact details for two to three academic referees.
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