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Inserm (National Institute of Health and Medical Research)
4 days ago
36-Month Postdoctoral Researcher in Protein Biochemistry, PERK Signaling and Cell Differentiation French National Institute for Health and Medical Research (Inserm) in France
Degree Level
Postdoc
Field of study
Cancer Biology
Funding
This is a 36-month fixed-term postdoctoral appointment with Inserm. The gross monthly salary follows the Inserm salary scale and depends on professional experience. Benefits include partial reimbursement of public transportation, subsidized catering, French social security benefits and paid annual leave.
Deadline
Jan 5, 2027
Country
France
University
Inserm (National Institute of Health and Medical Research)
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About this position
This postdoctoral position is part of the ANR-funded PIMPERK project at Inserm research units UMR_S 1236 and UMR_S 1242 in Rennes, France. The project investigates how PIM kinases regulate the eIF2α kinase PERK through phosphorylation and how this regulation affects protein secretion, cellular stress responses and cell differentiation.
The research combines expertise in plasma cell biology, B-cell immunology, protein synthesis and secretion with the study of endoplasmic reticulum signaling, ERN1-related mechanisms and cancer biology. The researcher will examine molecular links between kinase signaling, endoplasmic reticulum function and cellular differentiation, contributing to the discovery of previously uncharacterized regulatory mechanisms.
Research activities will focus on protein–protein interactions, kinase-dependent signaling and protein phosphorylation. The researcher will characterize PERK regulation and its functional effects in mammalian cellular models, including changes in signaling pathways, cell physiology and differentiation. Protein biochemistry and cell biology approaches will be used to dissect molecular mechanisms, analyze experimental data and support scientific publications and presentations.
The position is hosted in a collaborative, multidisciplinary environment involving the MOBIDIC and OSS research teams within BIOSIT. Available infrastructure includes advanced light and electron microscopy, flow cytometry, proteomics-related technologies and animal facilities. The researcher will also collaborate across the two teams, contribute to laboratory activities and co-supervise Master's students.
Scientific supervision is provided by Thierry Fest, an expert in plasma cell biology and B-cell immunology, and Eric Chevet, whose expertise includes endoplasmic reticulum biology, ERN1 signaling and cancer biology. The project offers an opportunity to develop scientific independence and strengthen an academic research profile in protein biochemistry, cell signaling and biomedical biology.
Funding details
This is a 36-month fixed-term postdoctoral appointment with Inserm. The gross monthly salary follows the Inserm salary scale and depends on professional experience. Benefits include partial reimbursement of public transportation, subsidized catering, French social security benefits and paid annual leave.
What's required
Applicants must hold a PhD in biochemistry, cell biology, molecular biology or a closely related discipline. Three to four years of postdoctoral experience are particularly encouraged. Essential experience includes protein biochemistry, cellular signaling, protein–protein interaction methods, protein phosphorylation and kinase signaling, mammalian cell culture, cell-based functional assays, independent research design, complex data interpretation and progressing findings toward publication. Experience with phosphoproteomics, proteomics or mass spectrometry, endoplasmic reticulum biology, cellular stress responses, protein secretion, immunoprecipitation or co-immunoprecipitation is desirable. Candidates should demonstrate scientific curiosity, creativity, organization, rigor, initiative, communication skills and an ability to work collaboratively. Professional written and spoken English is required; French is advantageous but not required.
How to apply
Submit a detailed CV including publications and technical expertise, a motivation letter explaining your research interests and suitability, and contact details for two to three academic referees. Apply through the Nature Careers application portal linked in the advert.
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