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Karolinska Institutet
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5 days ago
Postdoctoral Researcher in Single-Cell Epigenetics Karolinska Institutet in Sweden
Degree Level
Postdoc
Field of study
Computer Science
Funding
Available
Deadline
Nov 12, 2026
Country
Sweden
University
Karolinska Institutet
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About this position
The Lambo research team at the Department of Oncology-Pathology, Karolinska Institutet, is seeking a postdoctoral researcher to work on the epigenetic mechanisms that allow tumors to adapt to treatment. The project sits at the intersection of experimental perturbation, single-cell sequencing, computational analysis, and AI modelling, with a strong aim to connect basic tumor biology to clinical implementation.
The successful candidate will join an interdisciplinary cancer research environment in which preclinical and clinical research are closely integrated. The department includes more than 35 research groups and is based at Bioclinicum within Karolinska University Hospital, with part of the environment also located at Science for Life Laboratory. This provides access to advanced genomics, proteomics, metabolomics, spatial biology, imaging, and bioinformatics resources.
The research focuses on generating, processing, and interpreting single-cell DNA methylation data in pediatric cancers, particularly pediatric acute myeloid leukemia. A central part of the role is to help establish a recently developed method for generating single-cell methylation data at scale and then use those data to investigate pediatric tumor evolution. Because this is a relatively new data type, the postdoc will also have opportunities to develop novel computational methods for characterizing cell states, biological mechanisms, and state transitions.
The position involves close collaboration with experimental biologists to guide hypotheses, validate findings, and place biological observations into context. The postdoctoral researcher will also contribute to multimodal integration, data interpretation, study design, visualization, manuscript preparation, and the management of data associated with publications. The environment emphasizes creativity, independent thinking, and interdisciplinary teamwork within a leading medical university.
The work is embedded in a broader cancer research ecosystem with connections to the Swedish Childhood Tumor Biobank, the Theranostic Trial Center, and the Karolinska Comprehensive Cancer Center, supporting collaborative work that links discovery research with clinical translation.
Funding details
Available
What's required
A PhD or an equivalent foreign degree is required by the employment decision date. A degree completed within the last three years is considered an advantage, though earlier completion may be accepted for special reasons. Applicants should have documented experience in analyzing single-cell, single-nucleus and/or epigenetic datasets, strong programming skills in R and/or Python, experience handling large and complex biological datasets, and experience with alignment, quality control, data integration, and biological interpretation. They should be able to develop and troubleshoot computational approaches, ensure reproducibility, critically interpret results, communicate well in English, and work in an interdisciplinary environment. Additional merits include experience generating single-cell sequencing libraries, wet-lab experience, pediatric cancer data experience, DNA methylation experience, knowledge of epigenetic regulation in developmental biology, and published computational workflows or bioinformatic tools. Multidisciplinary candidates with both wet-lab and computational experience are prioritized.
How to apply
Prepare the required documents in English or Swedish: PhD certificate, a complete CV with thesis and academic details, full publication list, and a one-page summary of current work. Submit the application through the Varbi recruitment system by the deadline.
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