Postdoctoral Researcher – Molecular Virology (Vaccinology and Pathogenesis) KU Leuven in Belgium

The Molecular Vaccinology and Vaccine Discovery (MVVD) group at the Rega Institute, KU Leuven, invites applications for a postdoctoral researcher in molecular virology, focusing on vaccinology and pathogenesis. The group is internationally recognized for its research on yellow fever and related orthoflaviviruses, aiming to translate insights from viral pathogenesis and host immunity into innovative vaccine and therapeutic strategies. The research vision is guided by Reverse Vaccinology 3.0, emphasizing the transition from understanding pathology to intervention.

As a postdoctoral researcher, you will join a dynamic, multidisciplinary, and international team with access to state-of-the-art infrastructure, including high-containment BSL3 facilities, advanced imaging systems, and flow cytometry platforms. The position offers opportunities to contribute to both fundamental and translational research, including the development of next-generation vaccine technologies. You will take ownership of a research line, designing and coordinating in vitro and in vivo studies to investigate host-pathogen interactions in yellow fever and other orthoflavivirus infections. Responsibilities include developing and validating advanced methodologies for antibody characterization (ADE and ADCC assays), implementing yeast-surface display for mapping antibody-antigen interactions, and establishing systems for recombinant antigen expression. You will also contribute to the development and characterization of transgenic and knockout mouse and hamster models, essential for studying viral pathogenesis and immunity.

Beyond your own experiments, you will mentor junior researchers, supervise Master’s and PhD students, and guide technicians in daily operations. You will ensure rigorous data analysis, timely reporting, and achievement of project milestones. Active involvement in grant writing, scientific presentations, and collaborative initiatives is expected to strengthen the impact and sustainability of the research program.

Applicants must hold a PhD in virology, molecular biology, or a related field, with strong analytical skills, independent and collaborative work abilities, and excellent English communication skills. A proven publication record is essential. Relevant experience includes molecular cloning and plasmid design, lentiviral systems for gene delivery, CRISPR/Cas genome editing, recombinant protein and antigen expression, advanced immunological assays (ADE/ADCC), yeast-surface display, cell-based virus assays, and animal experimentation (FELASA B/C or equivalent). Familiarity with data analysis, bioinformatics, modeling for transcriptomics and immunoprofiling, and BSL3 laboratory procedures is advantageous.

The position is fully funded by KU Leuven, offering salary and benefits according to university standards. You will have access to cutting-edge technologies and a broad collaborative network within a stimulating research environment in Leuven, a historic city at the heart of Europe. KU Leuven is committed to diversity, inclusion, and equal opportunity, fostering an ambitious and respectful research and educational environment.

To apply, submit a motivation letter, CV, diploma and transcripts, contact details of at least two reference persons, and a list of publications via the KU Leuven job portal. For further information, contact Prof. dr. Kai Dallmeier or Dr. Lotte Coelmont by email. The application deadline is March 2, 2026.