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University of Southern California

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Postdoctoral Scholar Research Associate in Tau Seeding and Human Neuropathology University of Southern California in United States

Degree Level

Postdoc

Field of study

Biochemistry

Funding

NIH-funded research project; annual base salary range: $70,304-$80,000.

Deadline

Feb 25, 2027

Country flag

Country

United States

University

University of Southern California

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Keywords

Biochemistry
Molecular Biology
Pathology
Biology
Neuropsychology
Medical Science
Protein Aggregation
Neuropathology
Omics
Neurodegenerative Disease
Lipidomic
Metabolomic
Transcriptomic

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About this position

A postdoctoral scholar research associate position is available in the laboratory of Dr. Annie Hiniker at the University of Southern California. The project is NIH-funded and carried out in close collaboration with Dr. Allison Kraus at Case Western Reserve University.

The research asks when and where tau seeding first emerges in the normal human brain and how tau seeds are altered by age, co-pathologies, inflammatory responses, and regional molecular changes. The work centers on human neuropathology and aims to define the distribution, biochemical features, and cellular correlates of pathogenic tau seeds across aging and disease states.

The position combines several complementary approaches, including studies of well-characterized human brain tissue from control and neurodegenerative disease cohorts, neuropathologic analysis by immunohistochemistry and immunofluorescence, biochemical characterization, and transcriptomic and multiomic profiling. The project also integrates neuropathology with RT-QuIC and related seed amplification assays performed in the Kraus laboratory, linking human tissue findings to seeding activity and molecular state.

The Hiniker lab works broadly on human neuropathology, cell and molecular biology, and molecular profiling to identify mechanisms underlying neurodegenerative disease, with a particular focus on protein aggregation and degradation. The postdoctoral researcher will contribute to manuscript preparation, figures, abstracts, and presentations while working in a collaborative research environment spanning USC and Case Western Reserve University.

Funding details

NIH-funded research project; annual base salary range: $70,304-$80,000.

What's required

Applicants should hold, or soon receive, a Ph.D. or equivalent doctorate within the previous 4 years in neuroscience, molecular biology, biochemistry, pathology, or a related discipline. Preferred qualifications include a strong publication record, experience with neurodegenerative disease research, and experience with transcriptomic, metabolomic, lipidomic, or related molecular datasets.

How to apply

Apply through the USC Workday job posting using the provided application link. Current USC employees should apply through the internal USC Workday posting link. Contact USC Human Resources at (213) 821-8100 or [email protected] if you need application assistance.

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