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Predoctoral Researcher in GPCR Computational Drug Discovery and Cancer-Associated Mutations Hospital del Mar Research Institute in Spain
Degree Level
PhD
Field of study
Computer Science
Funding
Full-time predoctoral contract under the applicable FPI funding and employment regulations, with gross annual remuneration of €22,251.77. Contract formalization is conditional on a favorable FPI employment-call resolution. The selected candidate's start date can only be the first day of a month.
Country
Spain
University
Hospital del Mar
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About this position
The Hospital del Mar Research Institute is seeking a predoctoral researcher to join the G protein-coupled receptor (GPCR)-based drug discovery group led by Jana Selent at the Barcelona Biomedical Research Park (PRBB) in Barcelona, Spain.
The doctoral project examines how cancer-associated mutations modify the structure, dynamics, stability, signaling pathways, and ligand-recognition properties of GPCRs. The research will identify compounds that can selectively target oncogenic GPCR variants and restore dysfunctional receptor states, supporting the development of precision therapeutic strategies for cancer.
The researcher will conduct computational investigations of oncogenic GPCR variants using molecular modelling, molecular dynamics simulations, structural bioinformatics, ensemble-based virtual screening, and protein-ligand interaction analysis. The work will include generating conformational assemblies, identifying mutation-induced changes in receptor conformations and binding or allosteric sites, prioritizing compounds that stabilize functional receptor states, and integrating structural, dynamic, and pharmacological data.
The position involves collaboration with researchers from different disciplines to support experimental validation of computational findings. The researcher will also develop reproducible computational workflows, analyze large molecular-simulation datasets, contribute to scientific publications and presentations, and participate actively in group activities and doctoral training.
The research environment offers access to advanced scientific infrastructure, computational resources, and modern research platforms within the GPCR drug discovery laboratory at the Hospital del Mar Research Institute.
Funding details
Full-time predoctoral contract under the applicable FPI funding and employment regulations, with gross annual remuneration of €22,251.77. Contract formalization is conditional on a favorable FPI employment-call resolution. The selected candidate's start date can only be the first day of a month.
What's required
A Master's degree in Bioinformatics for Health Sciences is required. Candidates must be admitted to an accredited doctoral programme at the time of hiring and subsequently provide proof of formal enrolment. Required technical knowledge includes structural biology, structural bioinformatics, GPCR biology, molecular modelling, molecular dynamics simulations, protein-ligand interactions, molecular recognition, structure-based drug discovery, Python programming, large molecular-data analysis, computational workflows, and scientific data analysis. Familiarity with ACEMD, OpenMM, or GROMACS is expected. Additional merits include experimental structural biology, especially GPCR research, prior experience in computational drug discovery or molecular pharmacology, virtual screening, and high-performance computing. Candidates should have excellent spoken and written English, analytical and problem-solving abilities, motivation for a scientific research career, autonomy, teamwork, communication, organization, and scientific presentation skills.
How to apply
Apply through the temporary offer listed by the Hospital del Mar Research Institute using reference FIMIM3348-SELENT. Consult the advert's application instructions and submit the required candidacy materials through the institution's recruitment process.
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Review drafts and confirm requirements with the university.
Make your next move.
Prepare your application
Review drafts and confirm requirements with the university.