Launch week offerEnds in00h00m00s

Publisher
source

Hospital del Mar

Just Landed

Predoctoral Researcher in GPCR Computational Drug Discovery and Cancer-Associated Mutations Hospital del Mar Research Institute in Spain

Degree Level

PhD

Field of study

Computer Science

Funding

Full-time predoctoral contract under the applicable FPI funding and employment regulations, with gross annual remuneration of €22,251.77. Contract formalization is conditional on a favorable FPI employment-call resolution. The selected candidate's start date can only be the first day of a month.

Country flag

Country

Spain

University

Hospital del Mar

Apply for this position

Free with an ApplyKite account: the application link, the deadline in your tracker and a check of your fit.

Keywords

Computer Science
Chemistry
Biomedical Engineering
Biology
Structural Biology
Molecular Dynamics
Medical Science
Pharmacy
Virtual Screening
G Protein-coupled Receptor

Suggested positions

Publisher
source

Université de Lille

Country flag

France

Master 2 internship opportunity in the Pharmacy department of UFR3S at the University of Lille , France. The project focuses on accelerated virtual screening of the GPR35 receptor for inflammatory bowel disease , with an emphasis on identifying new selective GPR35 agonists, ideally biased toward the anti-inflammatory β-arrestin-2 pathway. The intern will work with Corentin Bedart in the In silico Lille research group (Inserm Unit U1286 INFINITE). Planned work includes: developing a complete deep...

Computer Science
Chemistry
Biomedical Engineering
+3 more

1 month ago

Publisher
source

George Washington University

Country flag

United States

George Washington University is advertising a Postdoctoral Associate position in the Chemistry Department focused on the design, synthesis, characterization, and evaluation of novel antibiotics and their prodrugs . The role is based at the Foggy Bottom campus in Washington, D.C., United States , and is an on-campus/in-person appointment. This postdoctoral research opportunity is centered on advanced experimental work in chemistry and drug discovery. The scientist will work with the PI, undergrad...

Chemistry
Biomedical Engineering
Biology
+2 more

3 weeks ago

Publisher
source

European Molecular Biology Laboratory Barcelona

Country flag

Spain

Fully funded postdoctoral position in proteasome regulation and targeted protein degradation at the Institute for Molecular Biology of Barcelona (IBMB-CSIC), Spain . The project is in the Regulation of the Proteasome and Targeted Protein Degradation Group , Department of Structural and Molecular Biology. This opportunity is well suited to candidates with interests in molecular biology , biochemistry , structural biology , genetic engineering , recombinant protein assays , and/or bioinformatics ....

Computer Science
Molecular Biology
Chemistry
+8 more

3 weeks ago

Publisher
source

Universitat Pompeu Fabra

Country flag

Spain

This postdoctoral project at Universitat Pompeu Fabra, Department of Engineering focuses on the biological risk of accelerated intervertebral disc degeneration in population cohorts. The selected researcher will work with subjects from the Northern Finland Birth Cohort , generating intervertebral disc models and linking them with quantitative or semi-quantitative biological regulation models. The research combines finite element simulations with morphometric and multi-omic data models to evaluat...

Computer Science
Biomedical Engineering
Biology
+2 more

Posted Yesterday

Publisher
source

Nick Polizzi

Dana-Farber Cancer Institute

Country flag

United States

Nick Polizzi is advertising two postdoc positions for new projects at Dana-Farber Cancer Institute / Harvard Medical School , with collaboration on one project with Ed Boyden’s group at MIT . The first project focuses on in situ protein sequencing , a highly interdisciplinary area spanning protein chemistry, biology, and advanced sequencing methods. The second project is on modeling cryptic pockets for drug discovery , which suggests computational structural biology, protein design, and translat...

Computer Science
Chemistry
Biomedical Engineering
+5 more

1 month ago

About this position

The Hospital del Mar Research Institute is seeking a predoctoral researcher to join the G protein-coupled receptor (GPCR)-based drug discovery group led by Jana Selent at the Barcelona Biomedical Research Park (PRBB) in Barcelona, Spain.

The doctoral project examines how cancer-associated mutations modify the structure, dynamics, stability, signaling pathways, and ligand-recognition properties of GPCRs. The research will identify compounds that can selectively target oncogenic GPCR variants and restore dysfunctional receptor states, supporting the development of precision therapeutic strategies for cancer.

The researcher will conduct computational investigations of oncogenic GPCR variants using molecular modelling, molecular dynamics simulations, structural bioinformatics, ensemble-based virtual screening, and protein-ligand interaction analysis. The work will include generating conformational assemblies, identifying mutation-induced changes in receptor conformations and binding or allosteric sites, prioritizing compounds that stabilize functional receptor states, and integrating structural, dynamic, and pharmacological data.

The position involves collaboration with researchers from different disciplines to support experimental validation of computational findings. The researcher will also develop reproducible computational workflows, analyze large molecular-simulation datasets, contribute to scientific publications and presentations, and participate actively in group activities and doctoral training.

The research environment offers access to advanced scientific infrastructure, computational resources, and modern research platforms within the GPCR drug discovery laboratory at the Hospital del Mar Research Institute.

Funding details

Full-time predoctoral contract under the applicable FPI funding and employment regulations, with gross annual remuneration of €22,251.77. Contract formalization is conditional on a favorable FPI employment-call resolution. The selected candidate's start date can only be the first day of a month.

What's required

A Master's degree in Bioinformatics for Health Sciences is required. Candidates must be admitted to an accredited doctoral programme at the time of hiring and subsequently provide proof of formal enrolment. Required technical knowledge includes structural biology, structural bioinformatics, GPCR biology, molecular modelling, molecular dynamics simulations, protein-ligand interactions, molecular recognition, structure-based drug discovery, Python programming, large molecular-data analysis, computational workflows, and scientific data analysis. Familiarity with ACEMD, OpenMM, or GROMACS is expected. Additional merits include experimental structural biology, especially GPCR research, prior experience in computational drug discovery or molecular pharmacology, virtual screening, and high-performance computing. Candidates should have excellent spoken and written English, analytical and problem-solving abilities, motivation for a scientific research career, autonomy, teamwork, communication, organization, and scientific presentation skills.

How to apply

Apply through the temporary offer listed by the Hospital del Mar Research Institute using reference FIMIM3348-SELENT. Consult the advert's application instructions and submit the required candidacy materials through the institution's recruitment process.

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts and confirm requirements with the university.