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Institut de Recerca Sant Pau
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R2B Senior Postdoctoral Researcher in Protein Nanocarrier Engineering and Cardiovascular Validation Institut d'Investigació Biomèdica Sant Pau in Spain
Degree Level
Postdoc
Field of study
Chemistry
Funding
Available
Deadline
Nov 23, 2026
Country
Spain
University
Institut de Recerca Sant Pau
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About this position
This senior postdoctoral position is based at the Institut d’Investigació Biomèdica Sant Pau and is jointly linked to two research groups: the Oncogenesis and Antitumor Drugs Research Group (GOA) and the Pathophysiology of Lipid-Related Diseases Research Group (PLRD). The project is an interdisciplinary bridge between protein-based nanocarrier engineering and in vivo preclinical cardiovascular validation.
The selected researcher will contribute to the European project UNSOLVED-CARDS, which addresses shared and sex-specific mechanisms in cardiovascular disease, including coronary artery disease, stroke, and abdominal aortic aneurysm. The work is designed to support the development of targeted therapies and personalized risk prediction tools.
Research activities combine nanomedicine, translational biology, and cardiovascular disease models. The postdoctoral researcher will design and engineer protein nanocarriers, carry out recombinant production and purification, and support their physicochemical characterization and conjugation for targeted delivery. The role also includes cellular biodistribution studies in vascular smooth muscle cells, endothelial cells, and macrophages, as well as translational work using human multi-omics candidates and mouse-model blood and plaque samples. In vivo work will include biodistribution imaging, pharmacokinetics, safety, and therapeutic efficacy evaluation in murine atherosclerosis models.
The position is led by Dr. Ugutz Unzueta and Dr. Noemí Rotllan, offering an environment that connects protein engineering, lipid-related disease research, and preclinical cardiovascular investigation.
Funding details
Available
What's required
A PhD degree in Biotechnology, Biochemistry, Biomedicine, or a related discipline is required. Candidates must have accredited training for personnel responsible for the design and performance of procedures involving laboratory animals (Functions B/C or FELASA accreditation). Proven experience in protein engineering and nanotechnology and/or murine models of cardiovascular diseases, particularly atherosclerosis, is required, together with strong motivation to work across both research fields. Oral and written proficiency in the two official languages of Catalonia is required; candidates who do not meet this must demonstrate adequate knowledge or commit to acquiring it within one year. An advanced level of English and advanced proficiency in office software tools such as Excel, Word, and PowerPoint are also required. Experience in molecular cloning, recombinant protein expression in E. coli, purification (IMAC, IEX, SEC), biophysical characterization (SDS-PAGE, DLS, ESI), protein conjugation, nanomaterial characterization, cell culture, flow cytometry, confocal microscopy, in vivo animal handling, cardiovascular disease models, IVIS imaging, histology, immunohistochemistry, immunofluorescence, and data analysis will be valued.
How to apply
Submit the application documents in PDF format by email to [email protected]. Include reference 2026/153 in the email. Attach a cover letter, updated CV, and signed authorization for personal data processing.
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