Abhisheak Sharma

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Assistant Director and Assistant Professor

University of Florida

United States

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Dr. Abhisheak Sharma serves as the Assistant Director and Assistant Professor at the University of Florida, USA. His research interests encompass the pharmacology and medicinal properties of plants, particularly focusing on substances like kratom and its derivatives. Recent publications highlight his work on drug interactions, pharmacokinetics, and the therapeutic potentials of various alkaloids.

Recent Grants

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Novel therapeutic development for breast cancer

Open Date: 2023-04-01

Close Date: 2026-03-31

Grant: Close

Kratom alkaloid exposure during pregnancy

Open Date: 2023-03-15

Close Date: 2025-02-28

Grant: Close

Kratom Alkaloid Exposure During Pregnancy

Open Date: 2023-03-01

Close Date: 2025-02-01

Grant: Close

Effects of cannabis on age-related cognitive decline and Alzheimer’s disease pathology

Open Date: 2021-08-15

Close Date: 2026-05-31

Grant: Close

Effects of cannabis on Alzheimer’s disease-related pathology and cognitive decline

Open Date: 2021-05-25

Close Date: 2023-02-28

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Christopher Robert McCurdy

Professor and Director

University of Florida

UNITED STATES

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Jianjun Chen

Professor

University of Florida

UNITED STATES

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Patrick J. Antonelli

UNITED STATES

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Abhisheak Sharma

Research Interests

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Recent Grants

Articles (30)

Cardio-pulmonary arrest in a patient revived with naloxone following reported use of 7-hydroxymitragynine

From Kratom to Semi‐Synthetic Opioids: The Rise and Risks of MGM‐15

A chromosome-level Mitragyna parvifolia genome unveils spirooxindole alkaloid diversification and mitraphylline biosynthesis

Discovery of CRBN-recruiting PROTAC degraders of the METTL3-METTL14 complex

Diversification of Kratom in US Markets: Results from an Online Survey and Chemical Assay of Products

Evaluating the drug interactions in kratom usage: clinical application

Uncaria attenuata and its main corynanthean alkaloid, villocarine A, exert antinociceptive effects in rats via activation of central μ-opioid receptors

Kratom: Botanical Insights and Cultivation Practices for a Conspicuous Medicinal Tree Species

Dual Opioid–Neuropeptide FF Small Molecule Ligands Demonstrate Analgesia with Reduced Tolerance Liabilities

Comprehensive pharmacokinetics and ADME evaluation of Akuamma alkaloids

Microbiome and Otic Quinolone Levels Following Tympanoplasty Assessed by Gelatin Sponge Analysis

Multimodal Image Fusion Workflow Incorporating MALDI Imaging Mass Spectrometry and Microscopy for the Study of Small Pharmaceutical Compounds

Multiple-Dose Pharmacokinetics and Safety of Mitragynine, the Major Alkaloid of Kratom, in Rats

Influence of Ethanol Concentration on the Extraction of Cannabinoid and Volatile Compounds for Dry-Hemped Beer

Perinatal Nicotine Vaping Exposure Induces Pro-myofibroblastic Phenotype in Rat Bone Marrow-derived Mesenchymal Stem Cells

Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation.

Explorations of Agonist Selectivity for the <i>α</i>9*nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation

Preclinical pharmacokinetic studies of villocarine A, an active Uncaria alkaloid.

Preclinical pharmacokinetic studies of villocarine A, an active Uncaria alkaloid

Microbiome and Otic Quinolone Levels Following Tympanoplasty Assessed by Gelatin Sponge Analysis

Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats

Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition

Receptor Selectivity and Therapeutic Potential of Kratom in Substance Use Disorders

Kratom Alkaloids: A Blueprint?

Comparative Pharmacokinetics of Commercially Available Cannabidiol Isolate, Broad-Spectrum, and Full-Spectrum Products

An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats

Oral IRAK-4 Inhibitor CA-4948 Is Blood-Brain Barrier Penetrant and Has Single-Agent Activity against CNS Lymphoma and Melanoma Brain Metastases

What Is the Kratom Overdose Risk? A Systematic Literature Review

Characterization of Different Forms of Kava (Piper methysticum) Products by UPLC-MS/MS

Variations in mitragynine content in the naturally growing Kratom (Mitragyna speciosa) population of Thailand

Collaborators (13)

Barry Setlow

Samuel Obeng

Satya Swathi Nadakuduti

Zhen Jia

Christina von Roemeling

Boone Prentice

Drew Budner

Francisco Leon

Kirsten Smith

Oliver Grundmann

Christopher Robert McCurdy

Jianjun Chen

Patrick J. Antonelli

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