Ad IJzerman

professor of medicinal chemistry

Universiteit Leiden Faculteit der Wiskunde en Natuurwetenschappen

Netherlands

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Ad IJzerman is a professor of medicinal chemistry at Universiteit Leiden Faculteit der Wiskunde en Natuurwetenschappen, Netherlands. His research focuses on solute carrier transporters, allosteric modulators of chemokine receptors, and ligand-directed covalent labeling of GPCRs. He has contributed to the understanding of membrane proteins as anticancer targets and has explored novel inhibitors in pharmacological studies.

Articles (17)

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2025

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2024

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2024

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2024

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2022

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2022

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2021

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2021

Collaborators (7)

Willem Jespers

Assistant Professor

Leiden University

NETHERLANDS

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Michael Emmerich

Associate Professor (UHD)

NETHERLANDS

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Jos H T Rohling

Assistant Professor

Leiden University Medical Center

NETHERLANDS

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Stefan Offermanns

Professor

Goethe University Frankfurt

GERMANY

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Stephan Michel

Assitant Professor

Leiden University Medical Center

NETHERLANDS

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Gerard van Westen

Full Professor AI & Medicinal Chemistry

Leiden University

NETHERLANDS

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Craig McArdle

Emeritus Professor of Molecular Pharmacology

University of Bristol

UNITED KINGDOM

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Ad IJzerman

Research Interests

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About

Articles (17)

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

N-Acyl-N-Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2B Receptor as Case Study

Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools

Small‐molecule CEM3 strengthens single‐cell oscillators in the suprachiasmatic nucleus

Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe

Pharmacological characterization of allosteric modulators: A case for chemokine receptors

Computational Characterization of Membrane Proteins as Anticancer Targets: Current Challenges and Opportunities

Gonadotrophin-releasing hormone receptors in GtoPdb v.2023.1

Hydroxycarboxylic acid receptors in GtoPdb v.2023.1

Proteochemometric Modeling Identifies Chemically Diverse Norepinephrine Transporter Inhibitors

Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors

Adenosine receptors in GtoPdb v.2023.1

A Chemical Biological Approach to Study G Protein-Coupled Receptors: Labeling the Adenosine A1 Receptor Using an Electrophilic Covalent Probe

Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology

MPP+-Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition

DrugEx v2: de novo design of drug molecules by Pareto-based multi-objective reinforcement learning in polypharmacology

Gonadotrophin-releasing hormone receptors in GtoPdb v.2021.3

Collaborators (7)

Willem Jespers

Michael Emmerich

Jos H T Rohling

Stefan Offermanns

Stephan Michel

Gerard van Westen

Craig McArdle

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