Adam Mieczkowski

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assistant professor

Institute of Biochemistry and Biophysics, Polish Academy of Sciences

Poland

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About

Adam Mieczkowski is an assistant professor at the Institute of Biochemistry and Biophysics, Polish Academy of Sciences. His research focuses on supramolecular chemistry, crystal structure analysis, and the development of new therapeutic strategies for antibiotic-resistant bacteria and cancer treatments. Recent publications include studies on the synthesis and applications of cyclonucleosides, heterocyclic polyamines, and multi-target-directed flavonoids for Alzheimer's disease, among others.

Recent Grants

Grant: Close

New generation of cytidine deaminase resistant, selective and low-toxic nucleosidic inhibitors of DNA polymerase: Design, synthesis and investigation of antitumor activity.

Open Date: 2012-04-01

Close Date: 2014-04-01

Grant: Close

Novel DNA minor groove helix alkylating agents - Design, synthesis and antitumor activity screening.

Open Date: 2011-12-01

Close Date: 2015-12-01

Grant: Close

Pyrimidine cyclonucleosides as convenient substrates for the synthesis of fused heterocyclic systems, Potential anxiolytic, antidepressant and anticonvulsant agents.

Open Date: 2010-01-01

Close Date: 2010-12-01

Articles (16)

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2021

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2021

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2021

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2021

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2020

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2020

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2020

Collaborators (19)

Dawid Warszycki

Institute of Pharmacology

POLAND

Adam Mieczkowski

Research Interests

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About

Recent Grants

Articles (16)

Recurrent Supramolecular Patterns in a Series of Salts of Heterocyclic Polyamines and Heterocyclic Dicarboxylic Acids: Synthesis, Single-Crystal X-ray Structure, Hirshfeld Surface Analysis, Energy Framework, and Quantum Chemical Calculations

Novel Salts of Heterocyclic Polyamines and 5-Sulfosalicylic Acid: Synthesis, Crystal Structure, and Hierarchical Supramolecular Interactions

Synthesis, Crystal Structure and Supramolecular Features of Novel 2,4-Diaminopyrimidine Salts

Triazolo[4,5-d]pyrimidin-5-amines based ERK3 inhibitors fail to demonstrate selective effects on adipocyte function

Dimeric Benzodiazepines as Peptide Mimetics to Overcome p53-Dependent Drug Resistance of Tumors

Conjugates of Aminoglycosides with Stapled Peptides as a Way to Target Antibiotic-Resistant Bacteria

Insights into molecular structure of adenosine-boron cluster conjugates and theirs phenyl isosters as adenosine receptor ligands: Nuclear magnetic resonance, crystallographic and computational studies

Synthesis and applications of cyclonucleosides: an update (2010–2023)

Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease

Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile

Improved HDAC Inhibition, Stronger Cytotoxic Effect and Higher Selectivity against Leukemias and Lymphomas of Novel, Tricyclic Vorinostat Analogues

Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold

Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists

Design and in Vitro Characterization of Tricyclic Benzodiazepine Derivatives as Potent and Selective Antileukemic Agents.

Internalization of the <i>Aspergillus nidulans</i> AstA Transporter into Mitochondria Depends on Growth Conditions, and Affects ATP Levels and Sulfite Oxidase Activity

Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs

Collaborators (19)

Dawid Warszycki

Katarzyna Bednarska-Szczepaniak

Elżbieta Grzesiuk

Keykavous Parang

Tomasz Przygodzki

Joanna Trylska

Krzysztof Wozniak

Małgorzata Podsiadła-Białoskórska

Monika Wojciechowska

Zyta M Ziora

Pawel Siedlecki

Igor Zhukov

Krzysztof Drabikowski

Sebastian Piłsyk

Joanna Kruszewska

Cezary Watala

Tomasz Frączyk

Speina Elzbieta

József Kardos

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