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Adam Sowalsky

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Senior Investigator

National Cancer Institute

United States

Research Interests

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Recent Grants

Grant: Close

Mechanisms of resistance to treatment in aggressive prostate cancers

Open Date: 2018-01-01

Close Date: 2018-12-31

Grant: Close

Development of Precision Neoadjuvant-Adjuvant Therapies

Open Date: 2016-09-30

Close Date: 2019-09-29

Grant: Close

Early detection of prostate cancer using circulating tumor DNA

Open Date: 2016-01-01

Close Date: 2016-12-31

Grant: Close

Mechanisms driving evolution of aggressive prostate cancer

Open Date: 2016-01-01

Close Date: 2016-12-31

Grant: Close

Molecular Features Distinguishing Gleason Grade 3 and Grade 4 Prostate Cancers

Open Date: 2013-09-23

Close Date: 2015-09-22

Articles (20)

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Collaborators (12)

Thomas O'Loughlin

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Mohammad Dezfulian

University of Pennsylvania

UNITED STATES

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Freddy E Escorcia

Investigator, Lasker Clinical Research Scholar, Distinguished Scholar | Head, Laboratory of Molecular Radiotherapy

National Cancer Institute

UNITED STATES

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Ines Figueiredo

Institute of Cancer Research

UNITED KINGDOM

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Adam Sharp

Team Leader

Institute of Cancer Research

UNITED KINGDOM

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Christopher J Lessard

Professor

Oklahoma Medical Research Foundation

UNITED STATES

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Seiji Arai

Gunma University

JAPAN

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Christopher J. Sweeney

University of Adelaide

AUSTRALIA

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Sanju Sinha

Assistant Professor

Sanford Burnham Prebys Medical Discovery Institute

UNITED STATES

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Tejas Patil

Assistant Professor

University of Colorado School of Medicine

UNITED STATES

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Jessica Hawley

Assistant Professor

University of Washington

UNITED STATES

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William D Figg

Senior Investigator, Lab Chief, Associate Director

National Institutes of Health

UNITED STATES

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Adam Sowalsky

Research Interests

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Recent Grants

Articles (20)

Androgen receptor splice variant 7 expression levels distinguish AR-mutated from nonmutated metastatic castration-resistant prostate cancers.

GZMK+CD8+T cells target a specific acinar cell type in Sj o€gren's disease

Localized high-risk prostate cancer harbors an androgen receptor activity–low subpopulation susceptible to HER2 inhibition

Phase II study of olaparib and durvalumab in patients with metastatic castration-resistant prostate cancer

Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer

Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7-Expressing CRPC Models.

Low tristetraprolin expression activates phenotypic plasticity and primes transition to lethal prostate cancer in mice

Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

Glypican-3 as a Radiotheranostic Target for Neuroendocrine Prostate Cancer

BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways.

ELOC-Mutated Renal Cell Carcinoma is a Rare Indolent Tumor With Distinctive Genomic Characteristics.

Radiogenomic Profiling of Prostate Tumors prior to External Beam Radiotherapy Converges on a Transcriptomic Signature of TGF-β Activity Driving Tumor Recurrence

A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics

Androgen receptor inhibition increases MHC Class I expression and improves immune response in prostate cancer

Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer.

Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates.

Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate-resistant prostate cancer.

Reproducible preclinical models of androgen receptor driven human prostate cancer bone metastasis.

Emerging Technologies and Diagnostics at the Gold Journal.

Defining biology and recurrence risk in prostate cancers treated by neoadjuvant chemohormonal therapy

Collaborators (12)

Thomas O'Loughlin

Mohammad Dezfulian

Freddy E Escorcia

Ines Figueiredo

Adam Sharp

Christopher J Lessard

Seiji Arai

Christopher J. Sweeney

Sanju Sinha

Tejas Patil

Jessica Hawley

William D Figg

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