Adel Nefzi

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Research Professor

Florida International University

United States

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About

Adel Nefzi is a Research Professor at Florida International University, USA. His research primarily focuses on drug discovery and the development of novel therapeutic agents, with recent articles discussing opioid affinity of compounds, targeting acetylcholinesterase in Alzheimer’s disease, and synthetic advances in thiazole compounds. He is also involved in exploring the interactive effects of therapeutic agents in various models.

Recent Grants

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Innovative approaches to oligoheterocyclic peptidomimetics

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Novel RORgamma antagonists for inflammation and autoimmune disease

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Identification of Small Molecule Amyloid Beta Peptide Reducing Agent

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LMTK3 inhibitors for the treatment of breast cancer

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High throughput screening for anti-adhesion drugs against placental and cerebral malaria

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Articles (17)

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2025

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2024

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2020

Collaborators (4)

Andrew Oleinikov

Professor

Florida Atlantic University

UNITED STATES

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Rudramani Pokhrel

University of Kansas Cancer Center

UNITED STATES

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Jay McLaughlin

Professor

University of Florida

UNITED STATES

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Lee-Yuan Liu-Chen

Professor

Temple University School of Medicine

UNITED STATES

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Adel Nefzi

Research Interests

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About

Recent Grants

Articles (17)

Opioid Affinity of Diazacyclic Peptidomimetic Compounds Derived from Reduced Polyamides

Targeting Acetylcholinesterase with Oxytocin: A New Avenue in Alzheimer’s Disease Therapeutics

Substituted Triazole-3,5-Diamine Compounds as Novel Human Topoisomerase III Beta Inhibitors

Interactive effects of morphine and the HIV integrase inhibitor, cabotegravir, in male and female mice

Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics

Recent synthetic advances in the preparation of 1,3-thiazole compounds and their therapeutic applications in degenerative diseases

Synthesis of Diazacyclic and Triazacyclic Small-Molecule Libraries Using Vicinal Chiral Diamines Generated from Modified Short Peptides and Their Application for Drug Discovery

Potential therapeutic use of dermaseptin S4 from the frog <i>Phyllomedusa sauvagii</i> and its derivatives against bacterial pathogens in fish

Screening, Deconvolution and Parallel Synthesis of Trisubstituted Piperazine and Trisubstituted 2,3-diketopierazine Libraries for the Rapid Identification of Antagonists of the Nuclear Retinoic Acid Receptor-related Orphan Receptor Gamma (RORγ)

Parallel Synthesis of Piperazine Tethered Thiazole Compounds with Antiplasmodial Activity

Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

1,5-Disubstituted Acylated 2-Amino-4,5-dihydroimidazoles as a New Class of Retinoic Acid Receptor–Related Orphan Receptor (ROR) Inhibitors

Encoding mu-opioid receptor biased agonism with interaction fingerprints

Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620

Small Molecule Compounds Identified from Mixture-Based Library Inhibit Binding between Plasmodium falciparum Infected Erythrocytes and Endothelial Receptor ICAM-1

Discovery of a Lead Compound for Specific Inhibition of Type I Collagen Production in Fibrosis

Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase

Collaborators (4)

Andrew Oleinikov

Rudramani Pokhrel

Jay McLaughlin

Lee-Yuan Liu-Chen

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