Lee-Yuan Liu-Chen

Professor

Temple University School of Medicine

United States

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Professor Lee-Yuan Liu-Chen is a faculty member at Temple University School of Medicine in the United States. His research primarily focuses on opioid receptors, particularly kappa opioid receptors, and their role in behaviors related to opioid use disorder. He has recently published articles investigating the pharmacological properties of novel opioid analgesics and the effects of kappa opioid receptor signaling in various behavioral contexts.

Articles (12)

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2025

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2025

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2025

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2025

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2024

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2024

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2024

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2022

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2022

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2022

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2021

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2020

Collaborators (2)

Yangmei Li

UNITED STATES

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Adel Nefzi

Research Professor

Florida International University

UNITED STATES

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Lee-Yuan Liu-Chen

Research Interests

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Articles (12)

Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics

Deletion of β-arrestin 2 in mice affects kappa opioid receptor-mediated behaviors depending on sex, ovariectomy status, and behavioral endpoints

KOR agonists for the treatment and/or prevention of opioid use disorder and cocaine use disorder

Pharmacological characterization of the novel selective kappa opioid receptor agonists 10-Iodo-Akuammicine and 10-Bromo-akuammicine in mice

Peptide-derived ligands for the discovery of safer opioid analgesics

Conformational Plasticity Enhances the Brain Penetration of a Metabolically Stable, Dual-Functional Opioid-Peptide CycloAnt

NCP, a Dual Kappa and mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties

A novel Oprm1-Cre mouse maintains endogenous expression, function and enables detailed molecular characterization of μ-opioid receptor cells

Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion

Agonist-promoted kappa opioid receptor (KOR) phosphorylation has behavioral endpoint-dependent and sex-specific effects

Exploring the Putative Mechanism of Allosteric Modulations By Mixed-Action Kappa/Mu Opioid Receptor Bitopic Modulators

Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects

Collaborators (2)

Yangmei Li

Adel Nefzi

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