Agnieszka Dobrzyn

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Director of the Institute, professor

Instytut Biologii Doswiadczalnej im M Nenckiego Polskiej Akademii Nauk

Poland

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About

Dr. Agnieszka Dobrzyn is a professor and the Director of the Institute at the Instytut Biologii Doswiadczalnej im M Nenckiego Polskiej Akademii Nauk in Poland. Her research focuses on lipid metabolism, mitochondrial function, and the molecular mechanisms underlying pancreatic diseases and obesity. Recent publications include studies on stearoyl-CoA desaturase's role in pancreatic β-cell health and the therapeutic potential of new antidiabetic compounds.

Recent Grants

Grant: Close

3D bioprinting of living pancreatic islets or insulin-producing cells into scafollds of bionic pancreas

Open Date: 2016-01-01

Close Date:

Grant: Close

Metabolic regulation of the DNA damage response in pancreatic beta cells in different models of type 2 diabetes

Open Date: 2015-01-01

Close Date:

Grant: Close

Rola lipidów w regulacji rozwoju wysp trzustkowych: nowa funkcja desaturazy stearoilo-CoA i lipazy monoacyloglicerolu

Open Date: 2014-06-10

Close Date: 2019-06-09

Grant: Close

Funkcjonalna analiza desaturazy stearoilo-CoA jako regulatora homeostazy metabolicznej i indukowanej przez kwasy tłuszczowe autofagii komórek beta trzustki

Open Date: 2012-09-11

Close Date: 2015-09-10

Grant: Close

Rola białka szoku cieplnego HSP72 w rozwoju insulinooporności indukowanej przez lipidy w mięśniach szkieletowych

Open Date: 2012-08-21

Close Date: 2016-08-20

Articles (10)

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (16)

Maciej Borowiec

Medical University of Lodz

POLAND

Agnieszka Dobrzyn

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About

Recent Grants

Articles (10)

Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas

Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic β-cells.

Diagnostic and therapeutic potential of protease inhibition.

Mitochondria-targeted anti-oxidant AntiOxCIN<sub>4</sub> improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems.

Breast cancer chemotherapy induces vascular dysfunction and hypertension through NOX4 dependent mechanism.

Investigation of the Therapeutic Potential of New Antidiabetic Compounds Using Islet-on-a-Chip Microfluidic Model.

Elevated level of lysophosphatidic acid among patients with HNF1B mutations and its role in RCAD syndrome: a multiomic study.

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Maternal Transmission of Human OGG1 Protects Mice Against Genetically- and Diet-Induced Obesity Through Increased Tissue Mitochondrial Content.

Impact of Porcine Pancreas Decellularization Conditions on the Quality of Obtained dECM.

Collaborators (16)

Maciej Borowiec

Ludgero Tavares

Aneta Dobosz

Wei Chen

José Teixeira

Anna Ajduk

Yaiza Potes

Sylwia Szymanska

Justyna Janikiewicz

Maciej Sierakowski

Priyanka Sharma

Agnieszka Karkucinska-Wieckowska

Elzbieta Jastrzebska

Susana P. Pereira

Michał Dąbrowski

Ivan Viegas

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