Justyna Janikiewicz

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Assistant Professor

Nencki Institute of Experimental Biology, Polish Academy of Sciences

Poland

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About

Justyna Janikiewicz is an Assistant Professor at the Nencki Institute of Experimental Biology, Polish Academy of Sciences, Poland. Her research focuses on neurodegeneration with brain iron accumulation, metabolic alterations in pancreatic cells, and the role of mitochondrial function in diseases such as non-alcoholic fatty liver disease (NAFLD). Recent publications include studies on fibroblast metabolism in NBIA and the impact of stearoyl-CoA desaturase 1 deficiency on pancreatic β-cell health.

Recent Grants

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Stearoyl-CoA desaturase 1 as a missing metabolic linker between lipid droplets storage and fatty acid-induced pancreatic beta cell failure

Open Date: 2016-12-01

Close Date: 2023-06-01

Articles (13)

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2020

Collaborators (18)

Maciej Borowiec

Medical University of Lodz

POLAND

Justyna Janikiewicz

Research Interests

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About

Recent Grants

Articles (13)

Assessment of the degree of disability of the Polish NBIA-MPAN population based on a patient survey

Metabolic alterations in fibroblasts of patients presenting with the MPAN subtype of neurodegeneration with brain iron accumulation (NBIA).

Metabolic impairments in neurodegeneration with brain iron accumulation.

Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas

Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic β-cells.

Mitochondria-targeted anti-oxidant AntiOxCIN<sub>4</sub> improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems.

Elevated level of lysophosphatidic acid among patients with HNF1B mutations and its role in RCAD syndrome: a multiomic study.

An intact zinc finger motif of the C1B domain is critical for stability and activity of diacylglycerol kinase-ε.

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Islet-on-a-chip: Biomimetic micropillar-based microfluidic system for three-dimensional pancreatic islet cell culture

Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response.

Combinations of regenerative medicine and Lab-on-a-chip systems: New hope to restoring the proper function of pancreatic islets in diabetes

Stearoyl-coa desaturase 1 activity determines the maintenance of DNMT1-mediated DNA methylation patterns in pancreatic β-cells

Collaborators (18)

Maciej Borowiec

Ludgero Tavares

Werner J.H. Koopman

Aneta Dobosz

José Teixeira

Anna Ajduk

Yaiza Potes

Sylwia Szymanska

Katarzyna Kwiatkowska

Mariusz Wieckowski

Agnieszka Dobrzyn

Agnieszka Karkucinska-Wieckowska

Elzbieta Jastrzebska

Magdalena Lebiedzińska-Arciszewska

Susana P. Pereira

Michał Dąbrowski

Pawel Dobrzyn

Ivan Viegas

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