Aideen Ryan

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Senior Lecturer

NUI Galway

Ireland

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Aideen Ryan is a Senior Lecturer at NUI Galway, Ireland. Her research focuses on the immunomodulatory roles of mesenchymal stromal cells and extracellular vesicles, with recent publications addressing topics such as inflammation in corneal injury and tumor microenvironment modulation. She also explores the therapeutic responses of stromal cells in various disease stages and the implications of glycosylation in disease progression.

Recent Grants

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CPD-DARA Translational study

Open Date: 2021-07-01

Close Date: 2023-07-01

Grant: Close

RESTORE - Sialylation as a target to reverse stromal cell mediated immunosuppression

Open Date: 2020-12-01

Close Date: 2024-12-01

Grant: Close

Development of 3D models of Colorectal Cancer

Open Date: 2019-09-01

Close Date: 2023-09-01

Grant: Close

Development of 3D models of Colorectal Cancer

Open Date: 2019-01-01

Close Date: 2021-01-01

Grant: Close

Development of 3D models of Colorectal Cancer

Open Date: 2019-01-01

Close Date: 2019-12-01

Aideen Ryan

Research Interests

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About

Recent Grants

Articles (21)

Small extracellular vesicles secreted from TGF-β1-licensed mesenchymal stromal cells reduce inflammation-associated injury following corneal alkali burn.

In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells.

The Tumour Glyco-Code: Sialylation as a Mediator of Stromal Cell Immunosuppression in the Tumour Microenvironment.

Comparison of in-vitro immunomodulatory capacity between large and small apoptotic bodies from human bone marrow mesenchymal stromal cells

Identification of disease-stage therapeutic responses of mesenchymal stromal cells retrieved from murine osteoarthritic joints

Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data

Tumor-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signaling

Increased Expression of the Sialyltransferase Gene <i>ST3GAL1</i> Predicts Lack of Sustained MRD Negativity and Increased Risk of Progression in Newly Diagnosed, Transplant Eligible Multiple Myeloma Patients in the Maintenance/Observation Phase of Cassiopeia Study

Immunomodulatory potential of cytokine-licensed human bone marrow-derived mesenchymal stromal cells correlates with potency marker expression profile

AB040. SOH24AB_104. Feasibility of establishment of a novel public and patient involvement (PPI) panel in multidisciplinary laboratory-based colorectal cancer research

Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment

Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies

Activation of innate-adaptive immune machinery by Poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer

Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer

CyBorD-DARA in Newly Diagnosed Transplant-Eligible Multiple Myeloma: Results from the 16-BCNI-001/CTRIAL-IE 16-02 Study Show High Rates of MRD Negativity at End of Treatment

TARGETING SIALIC ACID ON STROMAL CELLS REVERSES T CELL SUPPRESSION IN THE COLORECTAL TUMOUR MICROENVIRONMENT A NEW TUMOUR STROMAL CELL IMMUNE CHECKPOINT

Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer

Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

Stromal cell sialylation suppresses T cells in inflammatory tumour microenvironments: A new tumour stromal cell immune checkpoint?

Collaborators (9)

Sharon Glynn

Emma M. Kerr

Daniela Loessner

Philip Dunne

Alessandro Natoni

Daniel McVicar

David Wink

Simon McDade

Douglas Thomas

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