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Aideen Ryan

Senior Lecturer

NUI Galway

Ireland

Has grant

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Research Interests

Cell Biology

60%

Immunology

80%

Cancer Biology

80%

Inflammatory Biology

40%

T Cell Biology

30%

Epithelial-mesenchymal Transition

30%

Glycobiology

20%

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Recent Grants

Grant: Close

CPD-DARA Translational study

Open Date: 2021-07-01

Close Date: 2023-07-01

Grant: Close

RESTORE - Sialylation as a target to reverse stromal cell mediated immunosuppression

Open Date: 2020-12-01

Close Date: 2024-12-01

Grant: Close

Development of 3D models of Colorectal Cancer

Open Date: 2019-09-01

Close Date: 2023-09-01

Grant: Close

Development of 3D models of Colorectal Cancer

Open Date: 2019-01-01

Close Date: 2021-01-01

Grant: Close

Development of 3D models of Colorectal Cancer

Open Date: 2019-01-01

Close Date: 2019-12-01

Articles21

Small extracellular vesicles secreted from TGF-β1-licensed mesenchymal stromal cells reduce inflammation-associated injury following corneal alkali burn.

Article Link

Year:

2025

In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells.

Article Link

Year:

2025

The Tumour Glyco-Code: Sialylation as a Mediator of Stromal Cell Immunosuppression in the Tumour Microenvironment.

Article Link

Year:

2025

Comparison of in-vitro immunomodulatory capacity between large and small apoptotic bodies from human bone marrow mesenchymal stromal cells

Article Link

Year:

2025

Identification of disease-stage therapeutic responses of mesenchymal stromal cells retrieved from murine osteoarthritic joints

Article Link

Year:

2025

Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data

Article Link

Year:

2024

Tumor-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signaling

Article Link

Year:

2024

Increased Expression of the Sialyltransferase Gene <i>ST3GAL1</i> Predicts Lack of Sustained MRD Negativity and Increased Risk of Progression in Newly Diagnosed, Transplant Eligible Multiple Myeloma Patients in the Maintenance/Observation Phase of Cassiopeia Study

Article Link

Year:

2024

Immunomodulatory potential of cytokine-licensed human bone marrow-derived mesenchymal stromal cells correlates with potency marker expression profile

Article Link

Year:

2024

AB040. SOH24AB_104. Feasibility of establishment of a novel public and patient involvement (PPI) panel in multidisciplinary laboratory-based colorectal cancer research

Article Link

Year:

2024

Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment

Article Link

Year:

2023

Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies

Article Link

Year:

2023

Activation of innate-adaptive immune machinery by Poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer

Article Link

Year:

2022

Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer

Article Link

Year:

2022

CyBorD-DARA in Newly Diagnosed Transplant-Eligible Multiple Myeloma: Results from the 16-BCNI-001/CTRIAL-IE 16-02 Study Show High Rates of MRD Negativity at End of Treatment

Article Link

Year:

2022

TARGETING SIALIC ACID ON STROMAL CELLS REVERSES T CELL SUPPRESSION IN THE COLORECTAL TUMOUR MICROENVIRONMENT A NEW TUMOUR STROMAL CELL IMMUNE CHECKPOINT

Article Link

Year:

2022

Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer

Article Link

Year:

2021

Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer

Article Link

Year:

2021

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

Article Link

Year:

2021

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

Article Link

Year:

2021

Stromal cell sialylation suppresses T cells in inflammatory tumour microenvironments: A new tumour stromal cell immune checkpoint?

Article Link

Year:

2021

Collaborators9

Sharon Glynn

Associate Professor in Pathology

University of Galway

IRELAND

Emma M. Kerr

UNITED KINGDOM

Daniela Loessner

Professor

Leibniz-Institut für Polymerforschung eV

GERMANY

Philip Dunne

Reader in Molecular Pathology and Early Detection

UNITED KINGDOM

Alessandro Natoni

Sapienza University

ITALY

Daniel McVicar

Acting Chief

National Cancer Institute

UNITED STATES

David Wink

Acting Deputy Chief

National Cancer Institute

UNITED STATES

Simon McDade

The Queen's University Belfast

UNITED KINGDOM

Douglas Thomas

University of Chicago

UNITED STATES

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