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Alec Hirsch

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Associate professor

Oregon Health & Science University

United States

Research Interests

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Recent Grants

Grant: Close

Role of human apolipoprotein E isoforms in long-term effects of West Nile Virus exposure on Alzheimer's disease-related behavioral alteration, cognitive injury, neuroinflammation, and neuropathology

Open Date: 2023-05-15

Close Date: 2026-02-28

Grant: Close

Development of a Virus-Like Particle Vaccine for Powassan Virus

Open Date: 2020-06-01

Close Date: 2026-05-31

Grant: Close

Evaluation of Host miRNAs as Therapeutics against Encephalitogenic Flaviviruses

Open Date: 2012-06-01

Close Date: 2015-05-31

Articles (17)

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Collaborators (20)

Rahul D'Mello

Assistant Professor, Maternal-Fetal Medicine

Oregon Health & Science University

UNITED STATES

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Hans Oh

UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill

UNITED STATES

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Koen Van Rompay

Unit Leader, Infectious Diseases

University of California, Davis

UNITED STATES

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Peter Halfmann

Assistant Professor

University of Wisconsin-Madison

UNITED STATES

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Caralyn Labriola

Research Assistant Professor

Oregon Health & Science University

UNITED STATES

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Walid Abdelwahab

Research Assistant Professor

University of Montana Missoula

UNITED STATES

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Jamie Lo

Professor

Oregon Health & Science University

UNITED STATES

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Anne Lewis

Professor, Head of Pathology Services

Oregon National Primate Research Center

UNITED STATES

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Mohammad Anwar Hossain

Research Assistant Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Jacob Raber

Professor

UNITED STATES

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Aniruddha Das

Research Associate

Cleveland Clinic Lerner Research Institute

UNITED STATES

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Shubin Liu

University of North Carolina

UNITED STATES

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Nuno Rodrigues Faria

Professor in Virus Genomic Epidemiology

Imperial College London

UNITED KINGDOM

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Hod Dana

Assistant Professor

Case Western Reserve University School of Medicine

UNITED STATES

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Victoria H. J. Roberts

Associate Professor

Oregon Health & Science University

UNITED STATES

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Rachel Reader

Health Sciences Clinical Professor

University of California, Davis

UNITED STATES

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Nathaniel J. Moorman

University of North Carolina at Chapel Hill

UNITED STATES

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Jodi McBride

Oregon National Primate Research Center

UNITED STATES

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Jake Yue Chen

The University of Alabama

UNITED STATES

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Matthew Aliota

Faculty, Professor

University of Minnesota

UNITED STATES

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Alec Hirsch

Research Interests

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Recent Grants

Articles (17)

Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

Zika Virus: Research Priorities for Preparedness and Response 3 Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection

Exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the mouse brain

Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model

Targeting west nile virus replication by xanthine inhibitors

Exploration of 4′-fluoro fleximer nucleoside analogues as potential broad-spectrum antiviral agents

Novel tricycle expanded purine nucleosides with pan-viral activity

The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine

Intracranial injection of genetically modified, mosquito non-transmissible Zika virus: Safety in primates and ramifications for brain tumor therapy.

Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates

Effects of West Nile virus on behavioral and cognitive performance, cortical Aβ pathology, viral loads, and immune measures of middle-aged NL-G-F/E3 and NL-G-F/E4 mice

4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses

Development of a Powassan Virus-Like Particle Vaccine Adjuvanted with Novel Toll-Like Receptor Agonists

Effects of COVID-19 virus-like particles on the behavioral and cognitive performance of human apolipoprotein E targeted replacement mice

Systemic exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the living mouse brain

Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer?s disease

Collaborators (20)

Rahul D'Mello

Hans Oh

Koen Van Rompay

Peter Halfmann

Caralyn Labriola

Walid Abdelwahab

Jamie Lo

Anne Lewis

Mohammad Anwar Hossain

Jacob Raber

Aniruddha Das

Shubin Liu

Nuno Rodrigues Faria

Hod Dana

Victoria H. J. Roberts

Rachel Reader

Nathaniel J. Moorman

Jodi McBride

Jake Yue Chen

Matthew Aliota

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