Alessandro Castorina

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Associate Professor

University of Sydney

Australia

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Dr. Alessandro Castorina is an Associate Professor at the University of Technology Sydney, Australia. His research areas include neurodegeneration, bioactive compounds in plant extraction, cognitive function training in older adults, and the biological properties of neuropeptides. He has published recent articles focused on the links between ER stress and myelin homeostasis, cytotoxic effects of plant extracts, and adapted physical activity for children with autism spectrum disorder.

Recent Grants

Grant: Close

Azetidine-2-carboxylic acid - a plant-derived non-protein amino acid as a novel environmental risk factor for MS

Open Date: 2021-10-01

Close Date: 2022-09-01

Grant: Close

Neuropeptide-based approach to improve myelin repair in Multiple Sclerosis

Open Date: 2019-04-01

Close Date: 2023-03-01

Grant: Close

Profiling inflammation-associated microRNAs in a murine model of Multiple Sclerosis (MS): testing the efficacy of the neuropeptides PACAP, VIP and maxadilan

Open Date: 2018-08-01

Close Date: 2019-12-01

Grant: Close

In vitro identification of microRNA networks regulated by the endogenous bioactive neuropeptide PACAP in neuronal and glial cells exposed to immune and metabolic challenges

Open Date: 2017-06-01

Close Date: 2018-06-01

Grant: Close

Investigating the effects of neonatal lipopolysaccharide treatment on the expression of PACAP family members in an animal model of neuropathic injury

Open Date: 2017-01-01

Close Date: 2017-12-01

Articles (20)

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2022

Collaborators (11)

Iain Campbell

Professor of Molecular Biology and Head of School

University of Sydney

AUSTRALIA

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Piero Pavone

ITALY

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Giuseppe Musumeci

University of Catania

ITALY

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Catherine Gorrie

University of Sydney

AUSTRALIA

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Kevin A. Keay

AUSTRALIA

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Grant J. Logan

University of Sydney

AUSTRALIA

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Luca Petrigna

University of Catania

ITALY

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Sarah Thomas Broome

Karolinska Institutet

SWEDEN

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Kenneth Rodgers

University of Sydney

AUSTRALIA

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Sahar Ghorbanpour

Lecturer (level B)

University of Sydney

AUSTRALIA

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Stefan Rose-John

Professor and Head

Kiel University

GERMANY

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Alessandro Castorina

Research Interests

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About

Recent Grants

Articles (20)

PAC1 Receptor Knockout Mice Reveal Critical Links Between ER Stress, Myelin Homeostasis, and Neurodegeneration

Optimum heat reflux extraction of key bioactive compounds from lemon scented tea tree ( Leptospermum petersonii) leaves and their cytotoxic effects

A Standard Operating Procedure for Dual-Task Training to Improve Physical and Cognitive Function in Older Adults: A Scoping Review

VPAC1 and VPAC2 Receptor Heterozygosity Confers Distinct Biological Properties to BV2 Microglial Cells

Increased Expression of the Neuropeptides PACAP/VIP in the Brain of Mice with CNS Targeted Production of IL-6 Is Mediated in Part by Trans-Signalling

Adapted Physical Activity Programs for Children with Autism Spectrum Disorder and Neurotypical Children: Differences between Online and Face-to-Face Training

Exploring body composition and somatotype profiles among youth professional soccer players

Targeting the PAC1 receptor mitigates degradation of myelin and synaptic markers and diminishes locomotor deficits in the cuprizone demyelination model

Differential Expression of PACAP/VIP Receptors in the Post-Mortem CNS White Matter of Multiple Sclerosis Donors

Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma

L-Proline Prevents Endoplasmic Reticulum Stress in Microglial Cells Exposed to L-azetidine-2-carboxylic Acid

Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury

Altered Hippocampal and Striatal Expression of Endothelial Markers and VIP/PACAP Neuropeptides in a Mouse Model of Systemic Lupus Erythematosus

Identification of Key Genes and Regulatory Pathways in Multiple Sclerosis Brain Samples: A Meta-Analysis of Micro-Array Datasets

Molecular Assessment of Healthy Pathological Articular Cartilages in Physically Active People: A Scoping Review

Pro-Inflammatory and Pro-Apoptotic Effects of the Non-Protein Amino Acid L-Azetidine-2-Carboxylic Acid in BV2 Microglial Cells

Systemic Rotenone Administration Causes Extra-Nigral Alterations in C57BL/6 Mice

PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells

Effects of Exercise on Skeletal Muscle Pathophysiology in Huntington’s Disease

Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis

Collaborators (11)

Iain Campbell

Piero Pavone

Giuseppe Musumeci

Catherine Gorrie

Kevin A. Keay

Grant J. Logan

Luca Petrigna

Sarah Thomas Broome

Kenneth Rodgers

Sahar Ghorbanpour

Stefan Rose-John

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