Alessio Accardi

Associate Professor

Weill Cornell Medical College

United States

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About

Alessio Accardi is an Associate Professor at Weill Cornell Medical College in the United States. His research focuses on the structural and functional mechanisms underlying ion channels and scramblases, particularly in relation to lipid scrambling and ion selectivity. Recent publications highlight his work on topics such as the human apoptotic scramblase Xkr4 and the gating mechanisms of calcium-activated potassium channels.

Articles (10)

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2025

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2025

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2024

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2024

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2024

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2022

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2022

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2021

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Weill Cornell Medical College

UNITED STATES

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Alessio Accardi

Research Interests

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Articles (10)

Structure and function of the human apoptotic scramblase Xkr4

Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel

Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants

In or out of the groove? Mechanisms of lipid scrambling by TMEM16 proteins

Structural basis of closed groove scrambling by a TMEM16 protein

Backbone amides are determinants of Cl− selectivity in CLC ion channels

TMEM16 scramblases thin the membrane to enable lipid scrambling

Not so transport incompetent after all: Revisiting a CLC-7 mutant sheds new mechanistic light on lysosomal physiology

Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

What biologists want from their chloride reporters – a conversation between chemists and biologists

Collaborators (5)

Kallol Gupta

Christopher Ahern

Peter Goldstein

Sepehr Dehghani Ghahnaviyeh

Simon Scheuring

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