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Christopher Ahern

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Professor

Iowa State University

United States

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Recent Grants

Grant: Close

A Versatile Chemical-Genetic Approach to Examine Sodium Channelopathies

Open Date: 2019-07-01

Close Date: 2022-06-30

Grant: Close

The Facility for Atomic Mutagenesis

Open Date: 2017-12-01

Close Date: 2021-11-30

Grant: Close

Photochemical determination of sodium channel voltage-dependent gating and composition

Open Date: 2017-09-20

Close Date: 2021-08-31

Grant: Close

Chemical biology of voltage-gated sodium and potassium channels

Open Date: 2013-09-15

Close Date: 2018-05-31

Articles (17)

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Collaborators (9)

Artigas Pablo

Professor

Texas Tech University Health Sciences Center

UNITED STATES

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Erik Lindahl

Professor

Stockholm University

SWEDEN

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Alessio Accardi

Professor

Weill Cornell Medical College

UNITED STATES

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Marcel Goldschen-Ohm

Associate Professor

University of Texas at Austin

UNITED STATES

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Sepehr Dehghani Ghahnaviyeh

Beckman Institute for Advanced Science and Technology

UNITED STATES

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Robert Piper

Professor

Iowa State University

UNITED STATES

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Bente Vilsen

Professor

Aarhus University

DENMARK

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Aislinn Williams

Associate Professor

Iowa State University

UNITED STATES

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Rikke Holm Jensen

VIP, Associate Professor

Aarhus University

DENMARK

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Christopher Ahern

Research Interests

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Recent Grants

Articles (17)

Nonsense-mediated decay influences position-dependent effects of SCN2A premature stop codons on neuronal excitability and behavior

Programmed repair of disease-causing UGA premature termination codons in mammalian brain

Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis.

Chemical tuning reveals a cation–π gating bridge between the voltage-sensor and pore domains in the K v 7.1 potassium channel

A single main-chain hydrogen bond required to keep GABAA receptors closed

Non-canonical Sodium Channel Isoforms Underlie Chamber Specific Cardiac Excitability

Prevenying vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA

Genetic Code Expansion for Mechanistic Studies in Ion Channels: An (Un)natural Union of Chemistry and Biology

Conformational photo-trapping in NaV1.5: Inferring local motions at the “inactivation gate”

Transfer RNA mediated restoration of potassium conductance and electrical correction in premature termination Long-QT Syndrome hERG mutants

Real-time observation of functional specialization among phosphorylation sites in CFTR

Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel

Homomeric interactions of the MPZ Ig domain and their relation to Charcot-Marie-Tooth disease

Backbone amides are determinants of Cl− selectivity in CLC ion channels

Role of a conserved ion-binding site tyrosine in ion selectivity of the Na+/K+ pump

HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions

Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

Collaborators (9)

Artigas Pablo

Erik Lindahl

Alessio Accardi

Marcel Goldschen-Ohm

Sepehr Dehghani Ghahnaviyeh

Robert Piper

Bente Vilsen

Aislinn Williams

Rikke Holm Jensen

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