Alex K. Shalek

Associate Professor

Massachusetts Institute of Technology

United States

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Dr. Alex K. Shalek is an Associate Professor at the Massachusetts Institute of Technology, USA. His research focuses on the application of systems biology to human disease, employing single-cell analysis and multiomics techniques. Recent articles highlight his work in immune signaling, cell communication, and molecular programs in reproductive biology.

Articles (15)

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2025

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2020

Collaborators (10)

Kenneth Hoehn

Assistant Professor

Dartmouth College

UNITED STATES

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Elazer Edelman

Massachusetts Institute of Technology

UNITED STATES

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Musa Mhlanga

Professor

Radboud Universiteit Nijmegen Radboud Institute for Molecular Life Sciences

NETHERLANDS

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Catherine Blish

Association Professor

Stanford University School of Medicine

UNITED STATES

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Ruth Montgomery

Professor

Yale University School of Medicine

UNITED STATES

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Darrell Irvine

Professor

Massachusetts Institute of Technology

UNITED STATES

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Patricia Darrah

Staff Scientist and Head, TB Unit

National Institutes of Health

UNITED STATES

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Francesca E Duncan

UNITED STATES

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Matthew Sutton

National Institutes of Health

UNITED STATES

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Bryan Bryson

Massachusetts Institute of Technology

UNITED STATES

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Alex K. Shalek

Research Interests

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About

Articles (15)

High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways

Adapting systems biology to address the complexity of human disease in the single-cell era

Quantitative characterization of tissue states using multiomics and ecological spatial analysis

Carbohydrate-Lectin Interactions Reprogram Dendritic Cells to Promote Type 1 Anti-Tumor Immunity

Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense

Follicle-intrinsic and spatially distinct molecular programs drive follicle rupture and luteinization during ex vivo mammalian ovulation

Comparative analysis of cell–cell communication at single-cell resolution

NIAID workshop on T cell technologies

Single-Cell RNA Sequencing Reveals That Adaptation of Human Aortic Endothelial Cells to Antiproliferative Therapies Is Modulated by Flow-Induced Shear Stress

Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation

Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells

The Human Cell Atlas and equity: lessons learned

Evolution and Diversity of Immune Responses during Acute HIV Infection

Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets

Distribution and storage of inflammatory memory in barrier tissues

Collaborators (10)

Kenneth Hoehn

Elazer Edelman

Musa Mhlanga

Catherine Blish

Ruth Montgomery

Darrell Irvine

Patricia Darrah

Francesca E Duncan

Matthew Sutton

Bryan Bryson

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