Patricia Darrah

Staff Scientist and Head, TB Unit

National Institutes of Health

United States

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Patricia Darrah is a Staff Scientist and Head of the TB Unit at the National Institutes of Health in the United States. Her research focuses on the immune response to tuberculosis, particularly in relation to BCG vaccination. Recent publications include studies on the roles of CD4+ T cells and CD8α+ lymphocytes in TB protection and immune activation profiles following TLR agonist infusions.

Articles (10)

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2025

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2025

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2025

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2024

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2024

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2024

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2023

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2023

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2023

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2023

Collaborators (6)

Caylin Winchell

Assistant Professor

Chatham University

UNITED STATES

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Shu Wang

Assistant Professor

University of Toronto

CANADA

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Charles Scanga

P.I. / Research Associate Professor

University of Pittsburgh School of Medicine

UNITED STATES

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Matthew Sutton

National Institutes of Health

UNITED STATES

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Bryan Bryson

Massachusetts Institute of Technology

UNITED STATES

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Alex K. Shalek

Associate Professor

Massachusetts Institute of Technology

UNITED STATES

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Patricia Darrah

Research Interests

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Articles (10)

Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes

Deconvoluting the interplay of innate and adaptive immunity in BCG-induced nonspecific and TB-specific host resistance

High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways

Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques

Humoral correlates of protection against <i>Mycobacterium tuberculosis</i> following intravenous BCG vaccination in rhesus macaques.

Antibody-mediated depletion of select leukocyte subsets in blood and tissue of nonhuman primates.

Immune Activation Profiles Elicited by Distinct, Repeated TLR Agonist Infusions in Rhesus Macaques

Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis.

Blood transcriptional correlates of BCG-induced protection against tuberculosis in rhesus macaques.

Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques.

Collaborators (6)

Caylin Winchell

Shu Wang

Charles Scanga

Matthew Sutton

Bryan Bryson

Alex K. Shalek

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