Alexi Nott

Postdoctoral Researcher in Epigenomics & Alzheimer's Research at Imperial College London , in collaboration with King's College London and the UK Dementia Research Institute . This fully funded 3-year postdoctoral position sits within a new UK DRI Key Questions Award collaboration. The project will investigate the epigenome of oligodendrocytes and neuroimmune cell types in early Alzheimer's disease and resilience to dementia, using patient-derived samples , cell-type-enriched approaches, and single-nuclei multi-omics . The role is co-supervised across Imperial and King's College London with Sarah Marzi , and is part of a broader collaboration involving Dervis Salih (UCL) and Rikesh Rajani (University of Edinburgh). Research interests and keywords include epigenomics , neuroepigenomics , chromatin architecture , multi-omics , dementia , and Alzheimer's disease . The post is aimed at a motivated postdoctoral researcher with strong interest in brain disease biology and omics-based analysis. Funding is described as fully funded for 3 years. No deadline is stated in the post. Informal enquiries can be made by email, and applications should be submitted via the linked Imperial College London jobs portal. More information about the group is available on the Nott Lab website and Imperial/UK DRI profile pages.

Two full-time, fixed-term roles are open in the group of Alexi Nott at the UK Dementia Research Institute, Imperial College London (White City Campus). The positions focus on brain vascular epigenomics and dementia, building on recent work showing that the brain neurovascular unit is a key driver of genetic risk for small vessel disease and that epigenomic profiling of vascular cell types can help prioritise drug targets for dementia. Open roles • Research Associate (postdoc): hands-on epigenomics role involving CUT&Tag, ChIP-seq, and ATAC-seq, leading a translational project on vascular dysfunction in dementia. Salary: £50,733–£59,484 p.a. • Research Assistant (computational): bioinformatics-focused role analysing large-scale epigenomic and multi-omics datasets and building analysis pipelines using R, Python, Nextflow, and HPC. Salary: £43,863–£47,223 p.a. Both posts are funded by the Michael Uren Foundation and are based at Imperial's White City Campus in the United Kingdom. Deadlines • Research Assistant: 17 August 2026 • Research Associate (postdoc): 23 August 2026 How to apply Use the application links provided in the post for the relevant role. If you have questions, the poster invites interested candidates to reach out. Keywords: epigenomics, dementia, neuroscience, bioinformatics, multi-omics, vascular biology, small vessel disease, translational research.