Amita K. Manatunga

Modern medical devices are increasingly producing complex data that could offer deeper insights into physiological mechanisms of underlying diseases. One type of complex data that arises frequently in medical imaging studies is functional data, whose sampling unit is a smooth continuous function. In this work, with the goal of establishing the scientific validity of experiments involving modern medical imaging devices, we focus on the problem of evaluating reliability and reproducibility of multiple functional data that are measured on the same subjects by different methods (i.e. different technologies or raters). Specifically, we develop a series of intraclass correlation coefficient and concordance correlation coefficient indices that can assess intra-method, inter-method, and total (intra + inter) agreement based on multivariate multilevel functional data consisting of replicated functional data measurements produced by each of the different methods. For efficient estimation, the proposed indices are expressed using variance components of a multivariate multilevel functional mixed effect model, which can be smoothly estimated by functional principal component analysis. Extensive simulation studies are performed to assess the finite-sample properties of the estimators. The proposed method is applied to evaluate the reliability and reproducibility of renogram curves produced by a high-tech radionuclide image scan used to non-invasively detect kidney obstruction.