Anastassis Perrakis

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Head of Department

Antoni van Leeuwenhoek Nederlands Kanker Instituut

Netherlands

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About

Anastassis Perrakis is the Head of Department at the Antoni van Leeuwenhoek Nederlands Kanker Instituut in the Netherlands. His research areas encompass the signaling potential of GPI-anchored proteins, gene expression regulation via zinc finger transcription factors, and the structural implications of microtubule detyrosination. Additionally, he investigates cell motility through novel protein interactions and the determination of macromolecular structures.

Recent Grants

Grant: Close

Infrastructure for transnational access and discovery in structural biology

Open Date: 2020-02-01

Close Date: 2024-01-31

Grant: Close

Membrane glycerophosphodiesterases: novel players in cell differentiation and cancer biology

Open Date: 2017-01-01

Close Date: 2020-12-31

Grant: Close

World-wide E-infrastructure for structural biology

Open Date: 2015-11-01

Close Date: 2018-11-01

Grant: Close

Infrastructure for NMR, EM and X-ray crystallography for translational research

Open Date: 2015-09-01

Close Date: 2019-09-01

Grant: Close

Structural and chemical basis for the biosynthesis and propagation of base J

Open Date: 2014-09-01

Close Date: 2019-09-01

Articles (13)

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2025

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2025

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2023

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2023

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2023

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2023

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2022

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2022

Collaborators (8)

Robbie Joosten

Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital

NETHERLANDS

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Angela M Gronenborn

UPMC Rosalind Franklin Professor and Chair

University of Pittsburgh

UNITED STATES

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Xiao-chen Bai

Associate Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Andrea Thorn

Universität Hamburg

GERMANY

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Elisa Matas-Rico

Lecture Professor

University of Malaga

SPAIN

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Patrick Celie

head of facility

Antoni van Leeuwenhoek Nederlands Kanker Instituut

NETHERLANDS

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Daan Geerke

University of Amsterdam

NETHERLANDS

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Craig Jamieson

Professor

University Of Strathclyde

UNITED KINGDOM

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Anastassis Perrakis

Research Interests

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About

Recent Grants

Articles (13)

Unlocking the signaling potential of GPI-anchored proteins through lipolytic cleavage

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

JBP1 and JBP3 have conserved structures but different affinity to base-J

Challenges and opportunities in macromolecular structure determination

Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility

Decoding microtubule detyrosination: enzyme families, structures, and functional implications

Distant sequence regions of JBP1 contribute to J-DNA binding

AlphaFill: enriching AlphaFold models with ligands and cofactors

The CCP4 suite: integrative software for macromolecular crystallography

Autotaxin facilitates selective LPA receptor signaling

Extracting Modified Microtubules from Mammalian Cells to Study Microtubule-Protein Complexes by Cryo-Electron Microscopy

Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators

Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity

Collaborators (8)

Robbie Joosten

Angela M Gronenborn

Xiao-chen Bai

Andrea Thorn

Elisa Matas-Rico

Patrick Celie

Daan Geerke

Craig Jamieson

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