Andrea T. Franson

Background Palliative care (PC) provides numerous benefits for children with cancer. Pediatric patients with high‐grade glioma (HGG) are particularly well suited for early PC involvement given their high symptom burden and poor prognosis. However, studies continue to reveal that children with cancer, including HGG, have delayed PC involvement. We hypothesized that clinical trial enrollment may lead to a lack of or delay in PC involvement in this population. Procedure For each patient in our cohort of 43 pediatric patients with HGG, demographic, diagnostic, therapeutic, clinical trial enrollment, and PC information were collected. Statistical analysis was performed comparing PC characteristics between patients who did and did not enroll in a clinical trial. Results Seventy‐two percent of patients had at least one visit with a PC provider. Fifty‐six percent of patients enrolled in a clinical trial with HGG‐directed therapy. Seventy‐one percent of patients who enrolled in a clinical trial received specialty PC compared to 74% of non‐trial participants ( p = 1.000). Patients who enrolled in clinical trials received PC earlier in their disease course measured in days before death (mean = 177 days) compared to those who did not enroll (mean = 113 days, p = .180), though not statistically significant. Conclusions The prevalence of clinical trial enrollment is high in patients with HGG and will likely increase as the genomic/epigenomic landscape of these tumors is better understood. As such, our data reassuringly suggest that trial participation does not interfere with the receipt of specialty PC in this population.