Andrew Glazer

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Assistant Professor

Vanderbilt University Medical Center

United States

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Andrew Glazer is an Assistant Professor at Vanderbilt University Medical Center in the United States. His research focuses on cardiovascular medicine, particularly the classification and functional assessment of genetic variants related to cardiac conditions. He has contributed significantly to the development of guidelines and tools for variant effect predictions and has published extensively on topics such as splice-altering variants and high-throughput variant mapping.

Recent Grants

Grant: Close

A pipeline for identifying disease-causing variants in transmembrane proteins

Open Date: 2022-03-31

Close Date: 2025-02-28

Grant: Close

A pipeline for identifying disease-causing variants in transmembrane proteins

Open Date: 2020-03-06

Close Date: 2022-02-28

Grant: Close

High-throughput Discovery of Pathogenic Cardiac Sodium Channel Variants

Open Date: 2017-09-01

Close Date: 2019-10-31

Articles (21)

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2022

Collaborators (10)

Quinn Wells

UNITED STATES

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jonathan brown

Assistant Professor

Vanderbilt University Medical Center

UNITED STATES

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Jonathan Mosley

Associate Professor

Vanderbilt University Medical Center

UNITED STATES

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Adam Gordon

Assistant Professor

Northwestern University Feinberg School of Medicine

UNITED STATES

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Eric Farber-Eger

Vanderbilt University Medical Center

UNITED STATES

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Dmytro Kryshtal

Research Assistant Professor

Vanderbilt University Medical Center

UNITED STATES

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Christopher Johnson

Assisstant Professor (tenure track)

Mississippi State University

UNITED STATES

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Yuko Wada

UNITED STATES

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ALICAN GULSEVIN

Assistant Professor

Butler University

UNITED STATES

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Prince Kannankeril

Professor

Vanderbilt University Medical Center

UNITED STATES

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Andrew Glazer

Research Interests

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About

Recent Grants

Articles (21)

Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine.

Guidelines for releasing a variant effect predictor.

A high-performance extracellular field potential analyzer for iPSC-derived cardiomyocytes.

Multisite Validation of a Functional Assay to Adjudicate <i>SCN5A</i> Brugada Syndrome-Associated Variants.

High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology.

Minimum information and guidelines for reporting a multiplexed assay of variant effect.

The electrophysiologic effects of <i>KCNQ1</i> extend beyond expression of I<sub>Ks</sub>: evidence from genetic and pharmacologic block

Assays of Variant Effect and Automated Patch Clamping Improve <i>KCNH2</i>-LQTS Variant Classification and Cardiac Event Risk Stratification.

ParSE-seq: a calibrated multiplexed assay to facilitate the clinical classification of putative splice-altering variants

Multicenter clinical and functional evidence reclassifies a recurrent noncanonical filamin C splice-altering variant.

Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization

Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest

Multicenter clinical and functional evidence reclassifies a recurrent noncanonical<i> filamin</i> C splice-altering variant

An Atlas of Variant Effects to understand the genome at nucleotide resolution

Functional Assays Reclassify Suspected Splice-Altering Variants of Uncertain Significance in Mendelian Channelopathies

Genetics of congenital arrhythmia syndromes: the challenge of variant interpretation.

Dominant negative effects of SCN5A missense variants

Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes.

Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study

Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel NaV1.5

Common Ancestry-Specific Ion Channel Variants Predispose to Drug-Induced Arrhythmias

Collaborators (10)

Quinn Wells

jonathan brown

Jonathan Mosley

Adam Gordon

Eric Farber-Eger

Dmytro Kryshtal

Christopher Johnson

Yuko Wada

ALICAN GULSEVIN

Prince Kannankeril

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