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Andrew Huber

St. Jude Children's Research Hospital

United States

Research Interests

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Articles (14)

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2026

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2025

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2024

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2023

Collaborators (6)

Robert Ralston

Research Professor

University of Kansas Medical Center

UNITED STATES

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Wenwei Lin

Principal HTS Scientist

St. Jude Children's Research Hospital

UNITED STATES

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Thomas Dick

Professor

UNITED STATES

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Young-Hwan Jung

Assistant Professor

University of Texas Medical Branch at Galveston

UNITED STATES

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Ha Won Lee

Senior Scientist

St. Jude Children's Research Hospital

UNITED STATES

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Taosheng Chen

Full Member

St. Jude Children's Research Hospital

UNITED STATES

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Andrew Huber

Research Interests

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Articles (14)

Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors

PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network

First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy

A new mode of inhibition

Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR

CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Regulation of PXR in drug metabolism: chemical and structural perspectives

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

Collaborators (6)

Robert Ralston

Wenwei Lin

Thomas Dick

Young-Hwan Jung

Ha Won Lee

Taosheng Chen

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