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Taosheng Chen

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Full Member

St. Jude Children's Research Hospital

United States

Research Interests

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Recent Grants

Grant: Close

Regulation of xenobiotic receptors PXR and CAR: implications in drug disposition

Open Date: 2021-05-01

Close Date: 2026-03-01

Grant: Close

Regulation of drug disposition by a novel microRNA-mediated pathway

Open Date: 2014-05-01

Close Date: 2018-02-28

Grant: Close

Inhibitor of PAX3-FKHR as novel therapeutics for alveolar rhabdomyosarcoma

Open Date: 2010-07-01

Close Date: 2012-06-30

Grant: Close

Regulation of PXR by cell cycle and phosphorylation

Open Date: 2010-06-01

Close Date: 2017-03-31

Articles (20)

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Collaborators (8)

Daniel Harki

Professor

University of Minnesota

UNITED STATES

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Wenwei Lin

Principal HTS Scientist

St. Jude Children's Research Hospital

UNITED STATES

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Thomas Dick

Professor

UNITED STATES

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Andrew Huber

St. Jude Children's Research Hospital

UNITED STATES

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Gang Wu

Associate Member

St. Jude Children's Research Hospital

UNITED STATES

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Beisi Xu

Principal Bioinformatics Research Scientist

St. Jude Children's Research Hospital

UNITED STATES

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Richard E Lee

Member

St. Jude Children's Research Hospital

UNITED STATES

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Meritxell B. Cutrona

Head of Platform | Patient-derived organoids for Precision Medicine

Institut Gustave Roussy

FRANCE

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Taosheng Chen

Research Interests

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Recent Grants

Articles (20)

Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction

Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators

From biochemical time–resolved fluorescence resonance energy transfer assay to live cell nanobio-luminescence resonance energy transfer assay: A case study with the bromodomain-containing protein 4 protein

Direct targeting and regulation of RNA polymerase II by cell signaling kinases

rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry Data

Decoding the selective chemical modulation of CYP3A4

Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon cytochrome P450 3A5-targeted inhibition

Addition/Correction to “First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy”

PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network

Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases

First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy

A new mode of inhibition

Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Evaluation of a Pooling Chemoproteomics Strategy with an FDA-Approved Drug Library

Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

Collaborators (8)

Daniel Harki

Wenwei Lin

Thomas Dick

Andrew Huber

Gang Wu

Beisi Xu

Richard E Lee

Meritxell B. Cutrona

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