Andrew McIntosh

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Professor of Biological Psychiatry

University of Edinburgh

United Kingdom

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About

Andrew McIntosh is a Professor of Biological Psychiatry at the University of Edinburgh, UK. His research focuses on the genetic and biological underpinnings of major depressive disorder and its related traits, utilizing large-scale genomic data from diverse populations. His recent publications include studies on polygenic prediction, the role of inflammatory markers in depression, and the genetic architectures influencing adolescent depression trajectories.

Recent Grants

Grant: Close

Depression Genetics in Africa (DepGenAfrica)

Open Date: 2021-09-01

Close Date: 2026-08-31

Grant: Close

SCAMP Wave 2

Open Date: 2021-01-04

Close Date: 2026-01-03

Grant: Close

Exploiting genomic approaches to identify the environmental basis of depression

Open Date: 2021-01-01

Close Date: 2025-12-31

Grant: Close

Non-invasive biomarkers of stress in mothers, fathers and infants in urban and rural Malawi: a feasibility study

Open Date: 2021-01-01

Close Date: 2021-12-31

Grant: Close

A multi-omic investigation of Major Depressive Disorder and differential antidepressant response

Open Date: 2020-08-31

Close Date: 2024-08-30

Articles (23)

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2022

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2022

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2021

Collaborators (45)

Cathryn Lewis

King’s College London

UNITED KINGDOM

Andrew McIntosh

Research Interests

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About

Recent Grants

Articles (23)

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts

Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank

Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts.

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease.

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants

Generation Scotland

Childhood intelligence and risk of depression in later-life: A longitudinal data-linkage study

Cohort profile: The Scottish SHARE Mental Health (SHARE-MH) cohort – linkable survey, genetic and routinely collected data for mental health research

The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses

Prediction of antidepressant side effects in the Genetic Link to Anxiety and Depression Study

Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study

Predicting sex, age, general cognition and mental health with machine learning on brain structural connectomes

Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis

Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder

Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids

Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort

Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

Correction: Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank

Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank

Comparing personalized brain-based and genetic risk scores for major depressive disorder in large population samples of adults and adolescents

Early life predictors of late life cerebral small vessel disease in four prospective cohort studies

Collaborators (45)

Cathryn Lewis

Stephen Lawrie

Sang hyuck Lee

Gerome Breen

Sophia Frangou

Mark Bastin

Daniel Levey

Henry Rogers

Thomas D. Als

Keith Smith

Fabian Streit

Colin Palmer

Sonia Shah

Simon R. Cox

Gary Heiman

Erkki Isometsä

Iiris Hovatta

Saturnino Luz

Aleksandr Talishinsky

Alejo Nevado-Holgado

Chloe Fawns-Ritchie

Jakob Seidlitz

robin murray

Donald M. Lyall

Wonuola Akingbuwa

Søren Dalsgaard

Shuyang Yao

Michael Benros

Daniel McCartney

Martin Preisig

Petra E. Vértes

Daniel J Smith

Robert Free

Alison Murray

Ian Deary

Christopher Hübel

Elliot M. Tucker-Drob

Sundararajan Srinivasan

Jonathan Coleman

James Cole

Rosie Walker

Donald J MacIntyre

Johan Zvrskovec

Klaus-Peter Lesch

Yi Lu

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