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Andrii Monastyrskyi

Associate Professor & Member

H Lee Moffitt Cancer Center and Research Institute

United States

Research Interests

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Professors in United States Professors in Biochemistry Biochemistry professors in United States

Articles (20)

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2026

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Collaborators (12)

Justin Lopchuk

Associate Professor

Moffitt Cancer Center

UNITED STATES

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Matthias Geyer

Director

University of Bonn

GERMANY

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Ines Kaltheuner

University of Oxford

UNITED KINGDOM

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Solomon Tadesse

Assistant Professor

University of Idaho

UNITED STATES

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Pompom Ghosh

Research Scientist (Staff)

H Lee Moffitt Cancer Center and Research Institute

UNITED STATES

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Praneeth Reddy Sudalagunta

Applied Research Scientist II

H Lee Moffitt Cancer Center and Research Institute

UNITED STATES

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Chiara Borsari

Tenure-Track Assistant Professor (RTDB)

University of Milan

ITALY

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Ernst Schonbrunn

Senior member & Professor

Moffitt Cancer Center

UNITED STATES

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Eric Welsh

Senior Staff Scientist

H Lee Moffitt Cancer Center and Research Institute

UNITED STATES

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Oliver Hampton

Chief Data Officer

Southwest Research Institute

UNITED STATES

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Sameer Kulkarni

University of Sydney

AUSTRALIA

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Aleksandra Karolak

Assistant Professor - Secondary Appointment

Moffitt Cancer Center

UNITED STATES

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Andrii Monastyrskyi

Research Interests

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Articles (20)

Structure-Activity and Structure-Degradation Relationship Studies of 2-Amino-6-(benzimidazol-2-ylmethyl)-N9-heteroarylpurines as Potent and Selective CDK12/13 Inhibitors and Cyclin K Degraders.

Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors

Late-stage functionalization with strain-release warheads enables tunable covalent inhibition

Highlights from the Lowlands: Early Career Researchers Shine at Medicinal Chemistry Frontiers 2024

Discovery and design of molecular glue enhancers of CDK12–DDB1 interactions for targeted degradation of cyclin K

Discovery and optimization of purine-based CDK11 inhibitors for the treatment of Ewing's sarcoma

A chemoproteomic-enabled phenotypic library screen identifies KIF23 as a novel target in Ewing sarcoma

Chemoproteomic-enabled fragment-based drug discovery target identification in small cell lung cancer

Thiophene and benzo[b]thiophene

Structure-independent machine-learning predictions of the CDK12 interactome

Development of potent and selective ULK1/2 inhibitors based on 7-azain-dole scaffold with favorable in vivo properties

Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2

Investigating underlying efficacy and mechanism of action of the KIF11 inhibitor filanesib in Ewing and clear cell sarcomas

Going beyond Binary: Rapid Identification of Protein-Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma.

The reversible inhibitor SR-4835 binds Cdk12/Cyclin K in a non-canonical G-loop conformation

Targeting transcriptional elongation kinases prevents adaptation to KRASG12C inhibitors in both MAPK-dependent and -independent models of acquired resistance

Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione- Dependent Isomerase GSTZ1 as a Lung Cancer Target

Discovery of GSTZ1 as a novel target for drug refractory non-small cell lung cancer by using fragment-based chemical proteomics

Enantio- and Diastereoselective (Ipc)<sub>2</sub>BOTf-Mediated Aldol Reactions of Morpholine Carboxamides

Collaborators (12)

Justin Lopchuk

Matthias Geyer

Ines Kaltheuner

Solomon Tadesse

Pompom Ghosh

Praneeth Reddy Sudalagunta

Chiara Borsari

Ernst Schonbrunn

Eric Welsh

Oliver Hampton

Sameer Kulkarni

Aleksandra Karolak

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