Angelo Tome

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Assistant Professor

University of Coimbra

Portugal

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About

Dr. Angelo Tome is an Assistant Professor at the University of Coimbra, Portugal. His research primarily focuses on neurobiology, with recent articles investigating the amygdala NT3-TrkC pathway in fear extinction, the ergogenic effects of caffeine on the striatum, and the role of adenosine A2A receptors in contextual fear generalization and hippocampal long-term potentiation. His work contributes to our understanding of synaptic plasticity and neurodegenerative conditions.

Recent Grants

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Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress

Open Date: 2019-01-01

Close Date:

Grant: Close

Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer's disease: mechanisms and therapeutic prospects

Open Date: 2018-07-01

Close Date: 2021-06-01

Grant: Close

Tinkering with adenosine A2A receptors to control symptoms of Angelman syndrome

Open Date: 2018-02-01

Close Date: 2019-07-01

Grant: Close

Study of caffeine derivatives in the inhibition of Alzheimer's disease and as the basis to develop new therapeutics agents

Open Date: 2017-01-01

Close Date: 2018-01-01

Grant: Close

Hybrid ionotropic receptors: a new concept of receptor

Open Date: 2016-05-01

Close Date: 2018-10-01

Articles (17)

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2024

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2021

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2021

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2021

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2021

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2021

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2021

Collaborators (15)

Carlos Palmeira

Full Professor

University of Coimbra

PORTUGAL

Angelo Tome

Research Interests

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About

Recent Grants

Articles (17)

The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity

The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas

Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation

The striatum drives the ergogenic effects of caffeine

The striatum drives the ergogenic effects of caffeine

Adenosine A2A receptors control generalization of contextual fear in rats

Adenosine A<sub>2A</sub> receptors control generalization of contextual fear in rats

Adenosine A<sub>2A</sub> Receptors Shut Down Adenosine A<sub>1</sub> Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer's Disease

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am−/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Exercise decreases aberrant corticostriatal plasticity in an animal model of l-DOPA-induced dyskinesia.

Convergence of adenosine and GABA signaling for synapse stabilization during development

Use of knockout mice to explore CNS effects of adenosine

Exercise decreases aberrant corticostriatal plasticity in an animal model of L-DOPA-induced dyskinesia

Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

Collaborators (15)

Carlos Palmeira

Carla Sofia Gomes Silva

Garikoitz Azkona

Carlos B. Duarte

Henrique Silva

Christophe Bernard

Paula Agostinho

João Pedro Lopes

Xavier Nicol

Samira G. Ferreira

Anabela Rolo

Sabine Lévi

Nicolas Gervasi

Rodrigo Cunha

Marianne Renner

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