João Pedro Lopes

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University of Coimbra

Portugal

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Recent Grants

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Recetores A2A da adenosina como desencadeadores de disfunção mnemónica na doença de Alzheimer: mecanismos e possibilidade terapêutica

Open Date: 2018-07-01

Close Date: 2021-06-30

Grant: Close

Adenosine A2A receptors as triggers of memory dysfunction in Alzheimers disease: mechanisms and therapeutic propects

Open Date: 2018-07-01

Close Date:

Grant: Close

Strategies for healthy aging

Open Date: 2018-05-01

Close Date:

Grant: Close

Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress

Open Date: 2018-01-01

Close Date:

Grant: Close

Manipulation of A2A receptors to control symptoms of Angelman symdrome

Open Date: 2018-01-01

Close Date: 2019-06-01

Articles (10)

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2021

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2021

Collaborators (8)

Carlos Palmeira

Full Professor

University of Coimbra

PORTUGAL

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Angelo Tome

Assistant Professor

University of Coimbra

PORTUGAL

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Henrique Silva

Professor Associado

Universidade da Beira Interior Faculdade de Ciências da Saúde

PORTUGAL

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Paula Agostinho

PORTUGAL

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Samira G. Ferreira

University of Coimbra

PORTUGAL

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Anabela Rolo

Assistant Professor

University of Coimbra

PORTUGAL

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Rodrigo Cunha

Professor

Universidade do Porto Faculdade de Medicina

PORTUGAL

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Marlene F. Pereira

European Institute of Oncology

ITALY

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João Pedro Lopes

Research Interests

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Recent Grants

Articles (10)

Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ1–42 to Model Early Alzheimer’s Disease

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas

The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors

Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation

CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity

Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage

Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-β peptide exposure

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am−/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Collaborators (8)

Carlos Palmeira

Angelo Tome

Henrique Silva

Paula Agostinho

Samira G. Ferreira

Anabela Rolo

Rodrigo Cunha

Marlene F. Pereira

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